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| 神经生长因子在脑膜瘤细胞核中的表达及其临床意义 | |
| 引用本文： | 李巧玉,杨勇,袁志诚,陆培松,湛利平,王鹏,张焱,龚爱华,张志坚,封云,许文林.神经生长因子在脑膜瘤细胞核中的表达及其临床意义[J].中华实验外科杂志,2010,27(7). |
| 作者姓名： | 李巧玉 杨勇 袁志诚 陆培松 湛利平 王鹏 张焱 龚爱华 张志坚 封云 许文林 |
| 作者单位： | 1. 江苏大学附属人民医院神经外科,镇江,212002 2. 江苏大学基础医学与医学技术学院 3. 江苏大学附属人民医院中心实验室,镇江,212002 |
| 基金项目： | 国家自然科学基金青年基金，江苏省镇江市社会发展计划项目 |
| 摘 要： | 目的 探讨神经生长因子(NGF)在脑膜瘤中的表达及其临床意义.方法 对56例脑膜瘤切片进行NGF、孕激素受体(PR)、Ki67免疫组织化学染色,并随访患者脑膜瘤复发情况.结果 脑膜瘤中NGF核阳性率为41.1%,高于Ki67阳性率35.7%(P>0.05).PR阳性率为印.7%.NGF核阳性率与Ki67阳性率呈正相关(r=0.741,P<0.01),与PR阳性率呈负相关(r=-0.59,P<0.01).NGF核阳性组患者中位复发时间(36.000±2.484)个月明显短于NGF核阴性组(59.000±2.295)个月(P<0.01).结论 NGF核阳性率可以作为脑膜瘤细胞增殖活性及预后判断指标. |
| 关 键 词： | 脑膜瘤 神经生长因子 预后 |
Nuclear expression of nerve growth factor in meningioma and its clinical significance |
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| LI Qiao-yu,YANG Yong,YUAN Zhi-cheng,LU Pei-song,ZHAN Li-ping,WANG Peng,ZHANG Yan,GONG Ai-hua,ZHANG Zhi-jian,FENG Yun,XU Wen-lin.Nuclear expression of nerve growth factor in meningioma and its clinical significance[J].Chinese Journal of Experimental Surgery,2010,27(7). | |
| Authors: | LI Qiao-yu YANG Yong YUAN Zhi-cheng LU Pei-song ZHAN Li-ping WANG Peng ZHANG Yan GONG Ai-hua ZHANG Zhi-jian FENG Yun XU Wen-lin |
| Abstract: | Objective To investigate the expression of nerve growth factor (NGF) in meningioma and its biological significance. Methods Fifty-six cases of meningioma sections were immunohistochemi-cally stained with NGF, PR, Ki67 antibodies. Corresponding patients were followed up for recurrence of meningioma. Results NGF nuclear positive rate (41. 1% ) was higher than Ki67 positive rate (35. 7% ) (P>0.05 ). PR positive rate was 60. 7%. NGF nuclear positive rate was positively correlated with Ki67 positive rate (r =0. 741 ,P<0. 01), while negatively with PR positive rate (r = -0. 59,P<0.01). The median relapse time of NGF nuclear positive patients was 36. 000 ± 2. 484 months, which was significantly shorter than that of NGF nuclear negative group (59.000 ± 2. 295 months) (P <0.01 ). Conclusion NGF nuclear positive rate can be used as an indicator for proliferation and prognosis of meningioma. |
| Keywords: | Meningioma Nerve growth factor Prognosis |
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