| Antitumor Activities of Apple Extracts |
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| 作者姓名： | Peng Zhao Yan Zhuang Jianzhong Liu Xishan Hao Ming Liu Tianjin Cancer Institute & Hospital Tianjin Medical University Tianjin China. The Third Affiliated Hospital of Harbin Medical University Harbin China. |
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| 作者单位： | Peng Zhao Yan Zhuang Jianzhong Liu Xishan Hao Ming Liu Tianjin Cancer Institute & Hospital，Tianjin Medical University，Tianjin 300060，China. The Third Affiliated Hospital of Harbin Medical University，Harbin 150040，China. |
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| 基金项目： | This work was supported by the Overseas Chinese Scholars Fund of Educational Ministry, China (No. [2003] 406). |
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| 摘 要： | OBJECTIVE To examine the antitumor activities of fresh apple extracts. METHODS Fuji apple extracts were tested for their anti-LS~174T-pro-liferative activities, for their effect on expression of PCNA, and ability to induce apoptosis in a LS-174T cell line. RESULTS Apple extracts inhibited LS-174T cellular proliferation in a concentration and time dependent manner. The apple extracts equivalent to a concentration of 50 mg/ml inhibited the proliferation of the LS-174T cells by 34.5±1.2% after 48 h and 47.5±1.8% after 72 h respectively. Apple extracts inhibited PCNA expression and induced apoptosis of the LS-174T cells at concentrations above 12.5mg/ml. CONCLUSION Apple extracts can inhibit PCNA expression and induction of apoptosis in LS-174T cells which may contribute to their inhibitio-ry effect on cellular proliferation.
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| 收稿时间： | 24 October 2005 |
| 修稿时间： | 22 December 2005 |
Antitumor Activities of Apple Extracts |
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| Peng Zhao Yan Zhuang Jianzhong Liu Xishan Hao Ming Liu Tianjin Cancer Institute & Hospital,Tianjin Medical University,Tianjin ,China. The Third Affiliated Hospital of Harbin Medical University,Harbin ,China..Antitumor Activities of Apple Extracts[J].Chinese Journal of Clinical Oncology,2006,3(1):37-40. |
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| Authors: | Peng Zhao Yan Zhuang Jianzhong Liu Xishan Hao Ming Liu |
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| Institution: | 1. Tianjin Cancer Institute & Hospital,Tianjin Medical University, Tianjin 300060, China
2. The Third Affiliated Hospital of Harbin Medical University, Harbin 150040,China |
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| Abstract: | OBJECTIVE To examine the antitumor activities of fresh apple extracts.
METHODS Fuji apple extracts were tested for their anti-LS-174T-proliferative activities, for their effect on expression of PCNA,
and ability to induce apoptosis in a LS-174T cell line.
RESULTS Apple extracts inhibited LS-174T cellular proliferation in a concentration and time dependent manner. The apple extracts
equivalent to a concentration of 50 mg/ml inhibited the proliferation of the LS-174T cells by 34.5±1.2% after 48 h and 47.5±1.8%
after 72 h respectively. Apple extracts inhibited PCNA expression and induced apoptosis of the LS-174T cells at concentrations
above 12.5mg/ml.
CONCLUSION Apple extracts can inhibit PCNA expression and induction of apoptosis in LS-174T cells which may contribute to their inhibitiory
effect on cellular proliferation.
This work was supported by the Overseas Chinese Scholars Fund of Educational Ministry, China (No. 2003] 406). |
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| Keywords: | apple LS-174T cell lines phytochemicals PCNA apoptosis |
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