| 血管生成素及其Tie-2受体与2型糖尿病视网膜病变的相关性研究 |
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| 引用本文： | 尤巧英,朱麒钱,斯徐伟,王兴木.血管生成素及其Tie-2受体与2型糖尿病视网膜病变的相关性研究[J].中华内分泌代谢杂志,2011,27(8). |
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| 作者姓名： | 尤巧英 朱麒钱 斯徐伟 王兴木 |
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| 作者单位： | 1. 绍兴市人民医院内分泌代谢科,312000
2. 绍兴市人民医院检验科,312000 |
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| 摘 要： | 2型糖尿病增殖性视网膜病变(PDR)组血清血管生成素(Ang)2水平明显高于非增殖性视网膜病变组(NPDR)和2型糖尿病无视网膜病变组分别为5.80(3.83～8.00)、4.42(2.56～5.55)和2.75(1.40～4.64)ng/m1,P＜0.01],NPDR组高于2型糖尿病无视网膜病变组(P＜0.01);Ang-1在NPDR组高于2型糖尿病无视网膜病变组10.57(8.99～12.05)对9.21(7.71～11.2)ng/m1,P＜0.05];Tie-2受体在3组间差异无显著性(P＞0.05).提示血清Ang-2水平可能与2型糖尿病视网膜病变的严重程度相关.Abstract：Angiopoietin-2 levels were 5. 80 ( 3. 83-8. 00 ) , 4. 42 ( 2. 56-5. 55 ) , and 2. 75 ( l. 40-4. 64 )ng/ml in type 2 diabetic patients with proliferative retinopathy, patients with non-proliferative retinopathy, and patients without retinopathy, respectively. Statistical significances existed between any two groups (all P ＜0. 01 ). Angiopoietin-1 level in patients with non-proliferative retinopathy was higher than that in patients without retinopathy 10. 57 ( 8. 99-12. 05 ) vs 9. 21 (7. 71-11.2 ) ng/ml, P＜0. 05]. No difference in receptor Tie-2 was found among the 3 groups (P＞0. 05 ). The results suggested that serum angiopoietin-2 level might be associated with the severity of retinopathy in type 2 diabetic patients.
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| 关 键 词： | 血管生成素 受体 Tie-2 糖尿病 2型 视网膜病变 |
Association of angiopoietins and soluble angiopoietin receptor Tie-2 with diabetic retinopathy in patients with type 2 diabetes |
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| YOU Qiao-ying,ZHU Qi-qian,SI Xu-wei,WANG Xing-mu.Association of angiopoietins and soluble angiopoietin receptor Tie-2 with diabetic retinopathy in patients with type 2 diabetes[J].Chinese Journal of Endocrinology and Metabolism,2011,27(8). |
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| Authors: | YOU Qiao-ying ZHU Qi-qian SI Xu-wei WANG Xing-mu |
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| Abstract: | Angiopoietin-2 levels were 5. 80 ( 3. 83-8. 00 ) , 4. 42 ( 2. 56-5. 55 ) , and 2. 75 ( l. 40-4. 64 )ng/ml in type 2 diabetic patients with proliferative retinopathy, patients with non-proliferative retinopathy, and patients without retinopathy, respectively. Statistical significances existed between any two groups (all P ＜0. 01 ). Angiopoietin-1 level in patients with non-proliferative retinopathy was higher than that in patients without retinopathy 10. 57 ( 8. 99-12. 05 ) vs 9. 21 (7. 71-11.2 ) ng/ml, P＜0. 05]. No difference in receptor Tie-2 was found among the 3 groups (P＞0. 05 ). The results suggested that serum angiopoietin-2 level might be associated with the severity of retinopathy in type 2 diabetic patients. |
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| Keywords: | Angiopoietin Receptor Tie-2 Diabetes mellitus type 2 Retinopathy |
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