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肝缺血再灌注损伤对肿瘤增殖、转移的影响
引用本文:周伟平,孙汉勇. 肝缺血再灌注损伤对肿瘤增殖、转移的影响[J]. 世界华人消化杂志, 2010, 18(9)
作者姓名:周伟平  孙汉勇
作者单位:中国人民解放军第二军医大学东方肝胆外科医院肝外三科,上海市,200438;中国人民解放军第二军医大学东方肝胆外科医院肝外三科,上海市,200438
摘    要:肝缺血再灌注损伤(hepatic ischemia/reperfusion injury,HIRI)是肝脏外科常见的病理生理过程.HIRl通过引起趋化因子、黏附分子、基质金属蛋白酶、血管内皮细胞生长因子等细胞因子表达改变,对血液中残留肿瘤细胞的迁移、黏附、定植、生长等步骤有着重要的影响.与肝癌术后的复发、转移关系密切.

关 键 词:肝缺血再灌注损伤  细胞因子  肿瘤增殖  肿瘤转移

Effects of hepatic ischemia/reperfusion injury on tumor proliferation and metastasis
Wei-Ping Zhou,Han-Yong Sun. Effects of hepatic ischemia/reperfusion injury on tumor proliferation and metastasis[J]. World Chinese Journal of Digestology, 2010, 18(9)
Authors:Wei-Ping Zhou  Han-Yong Sun
Affiliation:Wei-Ping Zhou,Han-Yong Sun,the Third Department of Hepatic Surgery,Eastern Hepatobiliary Surgery Hospital,the Second Military Medical University of Chinese PLA,Shanghai 200438,China
Abstract:Hepatic ischemia/reperfusion injury (HIRI) is a common pathophysiological process encountered in liver surgery. It has significant effects on the migration, adhesion, colonization and growth of circulating tumor cells by affecting the expression of some cytokines such as chemokines, adhesion molecules, matrix metalloproteinases, and vas- cular endothelial growth factor. Therefore, HIRI is highly correlated with the postoperative recur- rence and metastasis of liver cancer.
Keywords:Hepatic ischemia/reperfusion injury  Cytokine  Tumor proliferation  Tumor metastasis  
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