Locally advanced breast cancer and postmastectomy radiotherapy |
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Authors: | Recht A |
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Affiliation: | Department of Radiation Oncology, Harvard Medical School, Boston, MA 02215, USA. arecht@caregroup.harvard.edu |
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Abstract: | Most patients with locally advanced breast cancer should be treated with a combination of chemotherapy, mastectomy (with immediate reconstruction if the patient so desires), and radiotherapy. Nonetheless, it seems reasonable to offer breast-conserving treatment to selected individuals who respond well to neoadjuvant therapy. Postmastectomy radiotherapy clearly reduces the risk of local-regional and distant failure for patients with earlier-stage invasive breast cancer with involved axillary lymph nodes. Certain subgroups of patients, however, may have such low local-regional failure rates that patients will not routinely find the benefits of radiotherapy sufficient to undergo such treatment. Further investigation of this issue is needed. |
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