| IVIG巴氏灭活的最佳条件 |
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| 引用本文： | 王焰,牟蕾,郑朝共. IVIG巴氏灭活的最佳条件[J]. 华西药学杂志, 2005, 20(6): 514-516 |
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| 作者姓名： | 王焰 牟蕾 郑朝共 |
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| 作者单位： | 成都蓉生药业有限责任公司,四川,成都,610023 |
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| 摘 要： | 目的为了提高静脉注射人免疫球蛋白(IVIG)制品的病毒安全性,探索其巴氏灭活的可行性。方法在不加保护剂的条件下,调整不同的蛋白浓度、pH、电导,对IVIG液体样品进行巴氏灭活,并作各种理化性质分析。结果以制品分子大小分布为主要指标,优选出蛋白浓度1.0%~1.5%、pH3.8~4.2、电导值低于0.3ms的巴氏灭活条件。结论所用条件可在不加保护剂的情况下进行巴氏灭活时,加热对静脉注射人免疫球蛋白制品性质影响最小。
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| 关 键 词： | 静脉注射人免疫球蛋白 巴氏灭活 病毒安全性 |
| 文章编号： | 1006-0103(2005)06-0514-03 |
| 收稿时间： | 2004-06-01 |
| 修稿时间： | 2004-06-01 |
The best condition for pasteurization of IVIG |
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| WANG Yan,MU Lei,ZHENG Chao-gong. The best condition for pasteurization of IVIG[J]. West China Journal of Pharmaceutical Sciences, 2005, 20(6): 514-516 |
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| Authors: | WANG Yan MU Lei ZHENG Chao-gong |
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| Affiliation: | Chengdu Rongsheng Pharmaceutical ltd. , Chengdu 610023, China |
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| Abstract: | OBJECTIVE To enhance the viral safety of human immunoglobulin for intravenous injection(IVIG) products and discuss the feasibility of pasteurization of IVIG products. METHODS We performanced a series of experiments with different protein concentrations,pH values and conductivity, and analyzed the effects on the characterizations of IVIG.RESULTS The best condition for pasteurization of IVIG was found.CONCLUSION This condition may make the effection of the characterizations of IVIG minimum. |
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| Keywords: | IVIG Pasteurization Viral safety |
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