早期肝硬化临床与病理诊断的对应关系

目的探讨早期肝硬化临床诊断与病理诊断的对应关系以及肝组织中HBV抗原表达与病理变化的关系。方法对688例临床诊断为早期肝硬化的患者进行肝穿刺活检,获取肝组织病理标本,经HE染色,网状纤维染色和Masson染色,统一读片做出病理诊断,并计算临床与病理诊断符合率。结果临床诊断与病理诊断相符者占66.73%,病理表现已形成典型肝硬化者占27.18%。肝组织HBcAg阳性者,肝细胞病变及纤维化程度均较重。结论早期肝硬化临床与病理诊断符合率低,肝活检病理学检查是不可替代的诊断方法。肝组织中HBcAg阳性者,病变程度重。

Study on the relationship between clinical and pathological diagnosis of liver cirrhosis at earlier period

Objective To investigate the relationship between clinical and pathological diagnosis of liver cirrhosis at earlier period,as well the relationship between the presentation of HBV antigen of hepatic tissue and pathological change.Method Needle biopsy was made for liver of 688 patients whose clinical diagnosis were liver cirrhosis at earlier perod,and pathology diagnosis was taken through stained with Hematoxylin-Enosin Rt(reticular fiber)staining or Masson staining,then accordance rate between clinical diagnosis and pathology diagnosis was computed.Results Diagnosis accordance rate between clinical diagnosis and pathology diagnosis was 66.73%,the typical cirrhosis was 27.18%.The patients whose HBV antigen presentation was positive,the pathological change and the degree of fibrosis were more serious.Conclusion The diagnosis accordance rate between clinical diagnosis and pathology diagnosis is lower,pathological examination of liver can not be replaced in the diagnosis of liver cirrhosis.The patients whose liver tissue HBcAg is positive have serious lesion.