TH1/TH2在慢性丙型肝炎发病机制中的作用

目的 研究Th1/Th2变化在慢性丙型肝炎发病机制中的作用。方法 采用双抗体酶联分析法检测了20例正常人，35例慢性丙型肝炎，30例慢性乙型肝炎患血清中的IFN－γ，IL-2，IL－4和IL－6的水平。结果 慢性丙型肝炎组Th2类细胞因子（IL－4，IL－6）水平明显高于正常对照组（P＜0．05），Th1类细胞因子水平IL－2也增高（P＜0．05），然而，Th1类细胞因子IFN－γ水平有增加趋势，但无统计学差异（P＞0．05）。Th2类细胞因子水平比Th1类细胞因子水平高。结论 Th2类细胞因子水平增高以及由此引起的Th1/Th2比值下降可能与慢性丙型肝炎的病程持续有关。

Roles of Th1/Th2 in pathogenesis of chronic hepatitis C

AIM To study the roles of Th1 and Th2 cytokines in chronics HCV infection. METHODS Serum levels of Th1 cytoines, interferon gamma (IFN gammn) and interleukin (IL) 2, and Th2 cytokines, IL 4 and IL 6, were measured by using enzyme linked immunosorbent assay. Thirty five individuals with chronic HCV infection, 20 healthy subjects as normal controls and 30 chronic HBV infected patients as disease controls were observed. RESULTS Th2 cytokines (IL 4 and IL 6) significantly increased in chronic HCV infected patients compared with normal controls ( P <0.05). Simi larly, the levels of Th1 cytokine (IL 2) also rose in individuals with chronic HCV infection as compared with normal controls ( P <0.05). However, Th1 cytokine IFN gamma level slightly increased, but there was no difference between chronic HCV infection and normal controls ( P >0.05). CONCLUSION Levels of Th2 cytokines are higher than Th1 cytokine in HCV infection. This suggests that there might exist a low ratio of Th1/Th2 in chronic HCV infected patients and an enhanced Th2 responses during HCV infection, which may partly be responsible for the persistence of HCV infection.