孤立性纤维性肿瘤临床病理特征

目的探讨孤立性纤维性肿瘤（SFT）的临床病理学特点、免疫学表型及鉴别诊断。方法对5例SFT进行临床病理学分析,并用免疫组化（S-P法）技术检测CD34、CD99、Vim Des CD68和S-100蛋白的表达。结果肿瘤主要由纤维母细胞样梭形细胞呈束状、编织状及席纹状排列,有丰富的胶原纤维及多量瘢痕形成,细胞无异型,核分裂少或无,CD34、CD99和Vim弥漫强阳性,而Des、CD68及S-100蛋白均阳性。结论SFT大多为良性,可以根据病理形态及免疫组化来加以诊断及鉴别诊断,当镜下出现细胞丰富、密集,细胞有异型性,核分裂相增多（〉4个/10个HPF）,明显的坏死和出血并侵犯周围组织时,要考虑恶性可能。

Clinicopathologic characteristics of solitary fibrous tumor

Objective To investigate the clinicopathologic characteristics and immunophenotype of the solitary fibrous tumor with emphasis on differential diagnosis. Methods Clinicopathological analysis of five cases of solitary fibrous tumor was performed with immnohistochemical study. Staining of CD34, CD99, vimentin, desmin, CD68 and S-100 protein was done by immunohistochemical SP method. Results Histologically the tumor was composed of fibroblast-like spindle cells, arranged in fascicles and storiform pattern. Tumor cells were strongly immunoreactive to CD34, CD99 and vimentin, while negative to desmin, CD68 and S-100 protein. Conclusion Most solitary fibrous tumors are benign tumors, and can be diagnosed by histological and immunohistoehemieal findings. When cytologic atypia, hemorrhage, necrosis and high mitotic activity are present, the solitary fibrous tumor may be malignant.