胸外科肿瘤患者手术中植入5-Fu缓释剂初步疗效观察

目的初步观察对胸外科肿瘤患者手术中植入氟尿嘧啶缓释剂的安全性。方法我科于2008年1月8日开始至2008年6月10日共治疗胸外科肿瘤患者80例,随机分为治疗组（手术中植入5-Fu缓释剂）和对照组（即常规手术）各40例。两组用药前后对照常规检查,心、肺、肝、肾功能,血、尿常规,肝、肾功能等指标。观察手术后引流量及并发症的发生情况。结果两组用药前后对照常规检查,治疗组手术后引流量较多,并发症未见增多,伤口愈合良好,未见延迟和不愈合。近期生活质量未见降低。结论手术中植入5-Fu缓释剂（即中人氟安）简便、易行、副作用少。

The safety of implanting sustained release 5-fluorouracil during operation in patients with thoracic neoplasms

Objective To investigate the safety of implanting sustained release 5-fluorouracil during operation for patients wilh tumor of the chest. Methods Eighty patients from January 8 to June 10 in 2008 were selected. Sustained release 5-fluorouracil was implanted in 40 cases with tumor of the chest during operation. Forty patients as control group underwent operation alone. The indexes of routine examination pre-and post-operation such as blood indexes, the function of heart, lung, liver and kidney, and the incidence of complications were compared. Results There were no significant differences of blood indexes and the function of heart, lung, liver and kidney between the two groups. There was more fluid drained in the group of sustained release 5-fluorouracil. Differences in other indexes were not found between the two groups. Conclusion Implanting sustained release 5-fluorouracil during operation is a safe and simple therapy with few side effects.