自体游离骨膜骨髓自固化磷酸钙复合移植治疗低负重或非负重部位节段性骨缺损的实验研究

Periosteum transplantation and bone transplantation are common methods in the treatment of segmental bone defect at present with unsatisfied effectiveness.OBJECTIVE: To discuss effectiveness of united transplantation of free periosteum-bone marrow-calcium phosphate(FP-BM-CPC) in the restoration of segmented bone defect.DESIGN: A self-coutrol prospective study was performed.SETTING and PARTICIPANTS: The study was completed in the Department of Orthopaedics, the Affiliated Hospital of Guilin Medical College and Department of Orthopaedics and Traumatology, the First Affiliated Hospital of Guangxi Medical University. Subjects were 15 New Zealand rabbits in either genders and with a body weight between 1.5 to 2.5 kg provided by Laboratort of Experimental Animals. Guangxi Medical University.METHODS: A bone defect model at 10 mm of midpiece in both radiuses of trialal rabbit was established. Trial group: one side of bone defect was restored by the transplantation of FP-BM-CPC: and the other side was taken as control group.MAIN OUTCOME MEASURES: X-ray plain films and histological exantinations for both radiuses affter 1.2. 4.6 and 8-week surgery.RESULTS: Bone defects in trial group were restored after 8-week injury but disunion in control group.CONCLUSION: United transplantation of FP-BM-CPC has good osteogenesis. which hopefully can be used as an effective method in the restoration of segmental bone defects in low-bearing or uon-hearing parts.