血清VEGF、bFGF与胃癌生物学行为的关系

目的:探讨VEGF、bFGF与胃癌的生物学行为的关系,复发转移患者血清VEGF、bFGF的表达水平与化疗疗效的关系。方法:应用ABC-ELISA方法检测胃癌患者血清VEGF、bFGF的表达情况。结果:(1)术前未作放化疗的胃癌组患者术前血清VEGF、bFGF表达水平明显高于健康体检者(P<0.05),也明显高于同组患者术后血清VEGF、bFGF表达水平(P<0.05)。(2)术前未作放化疗的胃癌组患者术前血清VEGF、bFGF的表达水平与原发肿瘤的浸润深度、TNM分期、淋巴结转移、远处转移有关。(3)术前未作放化疗的胃癌组患者术前血清VEGF与bFGF的表达水平呈正相关(r=0.439,P<0.01)。(4)胃癌患者复发转移组化疗前血清VEGF、bFGF的表达水平比健康体检者及无病生存组明显增高(P<0.05)。(5)胃癌患者复发转移组化疗后CR PR组血清VEGF、bFGF表达水平比化疗前明显减低(P<0.05),胃癌患者复发转移组化疗后NC PD组血清VEGF、bFGF表达水平比化疗前略高,但没有显著性差异(P>0.05),胃癌患者复发转移组化疗后CR PR组血清VEGF、bFGF表达水平比NC PD组明显低(P<0.05)。结论:胃癌患者血清VEGF、bFGF与胃癌生物学行为有关,而且与胃癌化疗疗效有关。血清VEGF、bFGF可能成为胃癌的诊断、术后随访、复发转移监测新的肿瘤标志物。

The relationship between the serum levels of vascular endothelial growth factor(vEGF)basic fibroblast growth factor(bFGF)as well as the biological behaviors of gastric cancer

Objective:To discuss the relationship between vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and the biological behaviors of gastric cancer and,the relationship between the serum levels of VEGF,bFGF and the chemotherapeutic efficacy in patients with recurrent and metastatic gastric cancer.Methods: The serum levels of VEGF and bFGF were detected by ABC-ELISA method.Results:(1) The serum levels of VEGF and bFGF were significantly higher in preoperative stomach cancer patients than those in the healthy controls(P<0.05) and postoperative stomach cancer patients(P<0.05).(2) The serum levels of VEGF and bFGF significantly correlated with the depth of invasion,TNM staging,lymph node metastasis,and distant metastasis of primary cancer.(3) The serum level of VEGF had positive correlation with the serum level of bFGF in gastric cancer patients before radiochemotherapy(r=0.439,P<0.01).(4) The levels of VEGF and bFGF are significantly higher in preoperative patients with recurrent and metastatic gastric cancer than that in healthy controls and disease-free survival subjects(P<0.05).After chemotherapy the serum levels of VEGF and bFGF in patients with no change(NC) or in progressive disease(PD) were a little higher than that before chemotherapy but the difference was not significant(P>0.05).(5) The serum levels of VEGF and bFGF were significantly lower in patients with complete response(CR) partial response(PR) than that with NC PD group after recurrent and metastatic patients received chemotherapy(P<0.05).Conclusion:The serum levels of VEGF and bFGF were related with biological behaviors and chemotherapeutic efficacy of gastric cancer.The serum levels of VEGF and bFGF may provide new markers for preoperative diagnosis,postoperative follow-up,monitoring of the metastasis or recurrence of gastric cancer.