| 补阳还五汤联合间充质干细胞移植对脑缺血再灌注损伤大鼠bFGF mRNA表达的影响 |
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| 引用本文： | 张运克,杨广华. 补阳还五汤联合间充质干细胞移植对脑缺血再灌注损伤大鼠bFGF mRNA表达的影响[J]. 中医杂志, 2011, 52(7): 589-591 |
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| 作者姓名： | 张运克 杨广华 |
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| 作者单位： | 1. 河南中医学院第一附属医院,河南省郑州市人民路19号,450000
2. 河南中医学院 |
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| 基金项目： | 河南省高校杰出科研人才创新工程项目，河南省杰出青年计划 |
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| 摘 要： | 目的探讨补阳还五汤联合骨髓间充质干细胞(MSCs)移植对脑缺血损伤的神经保护机制。方法将48只SD大鼠随机分为假手术组、模型组、MSCs移植组(MSCs组)、补阳还五汤联合MSCs移植组(联合组),每组12只。建立局灶性脑缺血再灌注模型,MSCs组、联合组从尾静脉注入MSCs,联合组并给予补阳还五汤,给药10天后检测碱性成纤维细胞生长因子(bFGF)基因表达情况。结果 MSCs组与联合组均能上调大鼠脑组织bFGFmRNA表达水平,与模型组和假手术组相比,差异均有统计学意义(P<0.05),联合组表达明显高于MSCs组(P<0.05)。结论补阳还五汤联合MSCs移植能通过上调脑组织bFGFmRNA表达水平,促进内源性神经营养因子bFGF基因表达而起对脑缺血再灌注损伤起保护作用。
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| 关 键 词： | 补阳还五汤 间充质干细胞 脑缺血再灌注损伤 成纤维细胞生长因子 |
Effect of Buyang Huanwu Decoction Combined with Mesenchymal Stem Cells Transplantation on the Expression of bFGF mRNA in Cerebral Ischemia-reperfusion Injury Rats |
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| ZHANG Yunke,YANG Guanghua. Effect of Buyang Huanwu Decoction Combined with Mesenchymal Stem Cells Transplantation on the Expression of bFGF mRNA in Cerebral Ischemia-reperfusion Injury Rats[J]. Journal of Traditional Chinese Medicine, 2011, 52(7): 589-591 |
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| Authors: | ZHANG Yunke YANG Guanghua |
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| Affiliation: | ZHANG Yunke1,YANG Guanghua2(1.The First Affiliated Hospital of Henan Univeristy of Chinese Medicine,Zhengzhou 450000,2.Henan University of Chinese Medicine) |
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| Abstract: | Objective To study the nerve protecting function of Buyang Huanwu Decoction(Decoction of invigorating yang for recuperation)combined with bone marrow mesenchymal stem cells(MSCs)transplantation for the cerebral ischemia injury.Methods Forty-eight SD rats were randomized into sham operation group,model group,MSCs transplantation group(MSCs group),and Buyang Huanwu Decoction combined with MSCs transplantation group(combined group)with 12 rats in each group.The models of focal cerebral ischemia-reperfusion wer... |
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| Keywords: | Buyang Huanwu Decoction(Decoction invigorating yang for recuperation) mesenchymal stem cells(MSCs) cerebral ischemia-reperfusion injury basic fibroblast growth factor(bFGF) |
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