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The accuracy of preoperative core biopsy in determining histologic grade, hormone receptors, and human epidermal growth factor receptor 2 status in invasive breast cancer |
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| Authors: | Park So Yeon Kim Ku Sang Lee Taek-Gu Park Sung-Shin Kim Sun Mi Han Wonshik Noh Dong-Young Kim Sung-Won |
| Institution: | a Department of Pathology, Seoul National University Bundang Hospital, Sungnamsi, Gyeonggido, Korea b Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam-Si, Gyeonggi-do 463-707, Korea c Department of Pathology, Daerim Saint Mary's Hospital, Seoul, Korea d Department of Radiology, Seoul National University Bundang Hospital, Sungnamsi, Gyeonggido, Korea e Department of Surgery, Seoul National University College of Medicine, Seoul, Korea |
| Abstract: | BackgroundProper determination of histologic type and biomarkers in a core biopsy specimen is important before preoperative systemic therapy. The purpose of this study was to determine the accuracy of preoperative core biopsy through comparative analysis of histologic grade (HG), hormone receptors, and human epidermal growth factor receptor 2 (HER-2) status in both the core biopsy and surgical specimens.MethodsWe identified 104 patients with invasive ductal cancer who underwent core biopsy and definitive surgery in our institution. The histologic type, HG, estrogen receptor (ER), progesterone receptor (PR), and HER-2 status were determined in both the core biopsy and surgical specimens by one pathologist.ResultsThe mean age of the 104 patients was 50 ± 9.9 years and the mean number of core biopsies was 5.1 ± .9. The concordance rates for histologic type, HG, ER, PR, and HER-2 status were 100%, 80.8%, 99%, 97.1%, and 86.5%, respectively.ConclusionsCore biopsy can predict histologic type, HG, ER, PR and HER-2 status preoperatively in breast cancer when used properly. |
| Keywords: | Core biopsy Histologic grade Estrogen receptor Progesterone receptor HER-2 |
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