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Accurate axillary lymph node dissection is feasible after neoadjuvant chemotherapy |
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| Authors: | Marieke E. Straver Emiel J.T. Rutgers Hester S.A. Oldenburg Jelle Wesseling Sabine C. Linn Nicola S. Russell Marie-Jeanne T.F.D. Vrancken Peeters |
| Affiliation: | a Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands b Department of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands c Department of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands d Department of Radiation Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands |
| Abstract: | BackgroundRecently, lower axillary lymph node retrieval after neoadjuvant chemotherapy was reported. We did not have this experience, and retrospectively analyzed our axillary lymph node dissections (ALNDs).MethodsOne hundred ninety-one patients who had ALND after neoadjuvant chemotherapy were compared with 192 patients with primary ALND after a positive sentinel node biopsy.ResultsThere were no differences in the mean number of nodes retrieved between the neoadjuvant group and the primary surgery group: 16.3 (range 4-38) and 15.8 (range 6-33), respectively (P = .4); or in the retrieval of fewer than 10 lymph nodes: 13/191 (7%) and 11/192 (6%) (P = .7). The number of cases with retrieval of more than 20 lymph nodes was higher in the neoadjuvant group: 42/191 (22%) versus 26/192 (13%) (P = .03). In the neoadjuvant group, 150/191 (79%) patients had residual lymph node metastasis after neoadjuvant chemotherapy.ConclusionOur results show the feasibility and need to remove enough lymph nodes to provide precise prognostic information and adequate local control. |
| Keywords: | Breast cancer Neoadjuvant chemotherapy Axillary lymph nodes |
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