| 复合物型肾小球肾炎病人免疫学发病机制实验研究 |
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| 引用本文： | 毕柳,李晓哲.复合物型肾小球肾炎病人免疫学发病机制实验研究[J].哈尔滨医科大学学报,1997,31(4):281-283. |
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| 作者姓名： | 毕柳 李晓哲 |
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| 作者单位： | [1]哈尔滨医科大学免疫学教研室 [2]基础医学院 |
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| 摘 要： | 肾小球肾炎是机体免疫调节功能异常，形成大量ＩＣ，在机体排除ＩＣ功能低下时，ＩＣ沉积于肾脏而致病。本实验结果证明，肾小球肾炎病人血清中ＣＩＣ、ｓＩＬ－２Ｒ显著高于正常人，Ｐ＜０．０１，ＣＭＣＳ显著低于正常人，Ｐ＜０．０１，ＴＮＦ、ＩＦＮ显著高于正常人，Ｐ＜０．０１，ＩＬ－８与ＩＬ－２两者无显著差异，Ｐ＜０．０５。从而证明，肾炎病人清除ＩＣ功能不强，血清中高水平的ＣＩＣ沉积于肾脏，引起肾脏损伤。
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| 关 键 词： | 慢性 肾小球肾炎 细胞因子 发病机制 免疫学 |
Exprimental Study of Immunological Pathogenesis Mechanism of ICGN |
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| Bi Liu et al.Exprimental Study of Immunological Pathogenesis Mechanism of ICGN[J].Journal of Harbin Medical University,1997,31(4):281-283. |
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| Authors: | Bi Liu |
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| Institution: | Department of Immunology |
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| Abstract: | This paper reports that GN is known to have close relation with immunoregulatory abnomality and is characterized by the deposition of IC in glomeruli.The experiment results showed that levels of CIC,sIL 2R,IL 8,IL 2,TNF and IFN were increased significantly,while CMSC was decreased markedly in patients of GN.The effects of CIC,CMSC and relevant cytokines in the mechanism of GN are also discussed in the paper. |
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| Keywords: | AESSR GN CIC CMSC CKs |
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