| 眼部淋巴组织增生性病变PCNA和AgNOR检测及其意义 |
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| 引用本文： | 魏锐利,叶挺军,楼月芳,奚寿增,刘会敏. 眼部淋巴组织增生性病变PCNA和AgNOR检测及其意义[J]. 解放军医学杂志, 1996, 0(4) |
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| 作者姓名： | 魏锐利 叶挺军 楼月芳 奚寿增 刘会敏 |
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| 作者单位： | 第二军区大学长征医院 |
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| 摘 要： | 眼部淋巴组织增生性病变ＰＣＮＡ和ＡｇＮＯＲ检测及其意义２００００３上海第二军区大学长征医院魏锐利，叶挺军，楼月芳，奚寿增，刘会敏关键词眼疾病；淋巴组织增生性疾病中国图书资料分类号Ｒ７３９．７收集我院眼部淋巴增生性病变石腊标本３４例（眼眶３１例，眼睑１...
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| 关 键 词： | 眼疾病；淋巴组织增生性疾病 |
CHARACTERISTICS AND BIOLOGICAL SIGNIFICANCE OF CHANGES IN CELLULAR DNA PLOIDY STATUS DURING COLORECTAL CARCINOGENESIS INDUCED BY N METHYL N NITROSOUREA IN MICE |
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| Wang Qiang,Fan Lieying,Wang Yuanhe et al. CHARACTERISTICS AND BIOLOGICAL SIGNIFICANCE OF CHANGES IN CELLULAR DNA PLOIDY STATUS DURING COLORECTAL CARCINOGENESIS INDUCED BY N METHYL N NITROSOUREA IN MICE[J]. Medical Journal of Chinese People's Liberation Army, 1996, 0(4) |
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| Authors: | Wang Qiang Fan Lieying Wang Yuanhe et al |
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| Affiliation: | Wang Qiang,Fan Lieying,Wang Yuanhe et al. Changzheng Hospital,Second Military Medical University,Shanghai 200003 |
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| Abstract: | The cellular DNA content during malignant transformation in the colon and rectum induced by N methyl N nitrosourea(MNU) in mice was quantitatively measured by image cytometry.In the normal adult mice, epithelial cells with diploid(2C) DNA content constitute the major cellular population. Under the persistent effect of MNU,the atavistic proliferation of 4C epithelial cells was obviously increased at the dysplasia stage,and the replaced 4C epithelial cells became the major cellular population.The induced cancer cells at their early canceration stage was characterized by predomination of DNA 4C cells,and at the following progression stage showed a selective and advantageous growth of aneuploid(AN) stemline cells obviously.The whole experimental colorectal carcinogenesis course showed a pattern of changing cellular DNA stemline from 2C to 4C to AN,which might be the essential biologic cytokinetic mechanism of the initiation and further progression of carcinoma of the colon and rectum. |
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| Keywords: | neoplasms experimental DNA ploidy N methyl N nitrosourea |
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