Anatomic and functional characteristics of the rat ileal pouch |
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Authors: | Chen Chiung-Nien McVay Laila D Batlivala Zubin S Hendren Samantha K Swain Gary P Salzman Nita Williams Noel N Rombeau John L |
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Institution: | Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
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Abstract: | BACKGROUND: The definitive operation for chronic ulcerative colitis (UC) and familial adenomatous polyposis is total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Mild inflammation (pouchitis) is omnipresent in pouches and becomes severe in 50% of UC patients with IPAA. The etiology of pouchitis is likely due to combined genetic, microbial, and immunologic factors. Epithelial cell exposure to surgical trauma and/or to changes in intestinal bacterial composition may account for the inflammatory infiltrate. Progress in understanding pouchitis is restricted by the lack of suitable animal models. METHODS: An ileal pouch-rectal anastomosis IPRA] in rats was developed to reproduce a model of human IPAA and clinical, gross and histologic criteria were determined. RESULTS: Many shared features with human ileal pouch were observed. CONCLUSION: IPRA is an important in vivo model to study mechanisms of repair, defense and immunity that may contribute to pouchitis. |
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Keywords: | Ileal pouch rectal anastomosis Pouchitis Peyer’s patches |
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