| 安定对兔体内苯妥因钠药代动力学的影响 |
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| 引用本文： | 周世文 杨媛媛. 安定对兔体内苯妥因钠药代动力学的影响[J]. 第三军医大学学报, 1992, 14(1): 32-34 |
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| 作者姓名： | 周世文 杨媛媛 |
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| 作者单位： | 第三军医大学新桥医院临床药理室 630037(周世文，杨媛媛，刘仁明，姚丹帆，李英衢)，第三军医大学新桥医院临床药理室 630037(康钦树) |
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| 摘 要： | 本文应用荧光偏振免疫分析法测定了家兔肌注安定前或1周后静注笨妥因钠的血药浓度,计算其药代动力学参数。结果表明,安定能明显影响兔体内苯妥因钠的药代功力学。12h时两组血药浓度相差非常显著,给安定后苯妥因钠的t_(1/2)明显延长,药代动力学模型由原来一室开放模型变为二室开放模型,而AUC和清除率无明显改变。
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| 关 键 词： | 安定 药效学 苯妥因 兔 药代动力学 |
The effects of diazepam on phenytoin pharmacokinetics in rabbits |
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| Zhou Shiwen,Yang Yuanyuan,Liu Retiming,et al. The effects of diazepam on phenytoin pharmacokinetics in rabbits[J]. Acta Academiae Medicinae Militaris Tertiae, 1992, 14(1): 32-34 |
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| Authors: | Zhou Shiwen Yang Yuanyuan Liu Retiming et al |
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| Abstract: | The serum level of intravenously dripped phenytoin was deter- mined in rabbits before and in different time intervals of a week after intramuscular injection of diazepam with fluorescence polarization immunoassay and the parameters were calculated on a microcomputer.It was found that in the 12th hour after diazepam injection,the serum level of phenytoin was significantly different from that of the control,and t1/2 of phenytoin was significantly prolonged;the model of pharmacokinetics of phenytoin was changed from one compartment open model to two compartment open model.Yet the AUC and Cl of phenytoin were not markedly altered. |
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| Keywords: | diazepam/PP phenytoin/ME kinetics rabbits |
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