基质金属蛋白酶MMP-3及其抑制因子TIMP-1 在子宫内膜异位症中的表达及意义

目的:评价基质金属蛋白酶-3(MMP-3)和基质金属蛋白酶组织抑制剂(TIMP-1)在子宫内膜异位症(EMs)中的表达,探讨它们在EMs的发生、发展中的作用。方法:用免疫组化检测MMP-3及TIMP-1在EMs的异位内膜组织(40例)及在位内膜组织(42例)中的表达,并与同期38例子宫正常内膜组织进行对比。结果:MMP-3在异位内膜中均高表达,与在位内膜组和正常内膜组织中的表达相比有统计学意义(P<0.01);TIMP-1在异位及在位内膜中均呈低表达,与正常内膜组织中的表达有统计学意义(P<0.01);异位内膜较在位内膜TIMP-1表达降低(P<0.01)。结论:异位内膜组织中的MMP-3过表达,而TIMP-1表达下降,两者间的比例失调使异位内膜组织更具侵袭性,这在EMs的发病机制中起着重要作用。

The Expression of Matix Metalloproteinase-3 and Tissue Inhibitor of Metalloproteinase-1 in Ectopic Endometriosis

Objective : To observe the expression of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1(TIMP-1) in endometriosis(EMs),and to study the possible roles of MMP-3 and TIMP-1 in the pathogenesis of EMs.Method: Immunohistochemical method was employed to detect the expression of MMP3 and TIMP-1 in ectopic endometrium(40 cases) and ectopic endometrium(42 cases) from women with EMs and normal endometrium(38 cases).Result: The levels of MMP-3 in ectopic endometrium tissues of EMs were significantly higher than those in the ectopic and normal endometrium(P < 0.01).The expression of TIMP-1 in ectopic and eutopic endometrium of EMs was lower than that in the normal endometrium.There was significant difference in the positive expression ratio between them(P < 0.01).Conclusion: The high expression of MMP-3 in EMs and lower expression of TIMP-1 in EMs resulting the higher ratio of MMP-3/TIMP-1 can contribute to the ectopic endometrium having stronger invasive ability than the normal endometrium.