中药仙贞片对气阴两虚兼肾虚血瘀2型糖尿病患者红细胞变形性的影响

目的 :在既往临床研究表明仙贞片有降血糖、抗自由基损伤 ,改善红细胞膜钠、钾ATP酶的基础上 ,进一步探讨仙贞片对糖尿病患者血液流变学的影响。方法 :采用激光衍射法观察 60例气阴两虚兼肾虚血瘀 2型糖尿病患者的红细胞变形及聚集能力 ,并对其中的 3 0例给予仙贞片治疗 8周。结果 :(1 ) 60例 2型糖尿病患者的红细胞变形性低于 40名健康人对照组 (P <0 0 0 1 ) ,而红细胞聚集指数则高于对照组 (P <0 0 0 1 )。相关检验显示 ,2型糖尿病患者的红细胞变形性与血浆纤维蛋白原水平呈负相关 ,P <0 0 5 ;而与胆固醇水平呈正相关 ,P <0 0 5。 (2 ) 3 0例仙贞片治疗组治疗后红细胞变形性升高 ,与治疗前相比有显著性差异 (P <0 0 5 ) ;血浆纤维蛋白原及空腹血糖降低 ,与治疗前比较有显著性差异 (P <0 0 5 ) ;与 3 0例观察组相比 ,以上指标亦有显著性差异 (P <0 0 5或P <0 0 1 )。结论 :仙贞片具有改善 2型糖尿病患者红细胞变形性的作用。

Effects of Chinese Herbs XianzhenTablet on the Deformability of Erythrocyte in Non-Insulin-Dependent Diabetes Mellitus Patients with Deficiency of Both Qi and Yin and Deficiency of Kidney with Blood Stasis

Objective: To explore the effects of Xianzhen Tablet (XZT) on the hemorheology of type 2 diabetes (NIDDM) on the basis of previous studies in XZT, that have indicated its ability to deplete fasting blood glucose, to reduce the injury of free radical to the body, to improve the Na K ATPase in the erythrocyte membrane of NIDDM. Methods: Erythrocyte deformability and aggregation were studied with Ektacytometer in a total of 60 type 2 diabetes who were randomly divided into two groups. One was ZXT treated group, another was placebo group. Results: (1) The erythrocyte deformability of type 2 diabetes was lower than that in normal subjects (P<0 001), but the erythrocyte aggregation increased abnormally than that of health people (P<0 001). The correlation test indicated there were negative correlation with plasma fibrinogen and positive correlation with blood cholesterol (P<0 05). (2) The erythrocyte deformability in the ZXT treated group with 30 patients improved after 8 weeks treatment (P<0 01), with the decreased fasting blood glucose and plasma fibrinogen (P<0 05). Compared with placebo group, there was significant statistical difference (P<0 01). Conclusions: XZT could improve the erythrocyte deformability in the type 2 diabetes.