结核杆菌感染C-反应蛋白检测的临床意义

目的探讨血清C-反应蛋白(CRP)检测在结核感染中的临床意义。方法选取2009年门诊PPD试验强阳性(观察组)50例和PPD试验阴性(对照组)健康者50名,用免疫速率散射比浊法检测血清CRP浓度,分析两组CRP结果的差异性以及观察组PPD试验平均直径与CRP检测浓度的相关性。采用t'检验、χ2检验、Spearman相关分析进行统计学分析。结果 CRP浓度观察组(3.00±4.53)mg/L,对照组(1.90±1.77)mg/L,差异无统计学意义(t'=1.5993,P0.05);两组CRP浓度阳性率分别为8.00%和2.00%,差异亦无统计学意义(χ2=0.8421,P0.05);观察组PPD试验平均直径与CRP检测浓度之间无相关性(r=0.160,P=0.134)。结论结核感染不会导致血清CRP浓度升高。

Clinical Significance of C - reactive Protein Detection in Mycobacterium Tuberculosis Infection.

Objective To evaluate the clinical significance of C - reactive protein （CRP） detection in mycobacterium tuberculosis infection. Methods Close contacts of tuberculosis patients and healthy cases who visited the special clinic of tuberculosis from January to September, 2009 were selected. PPD -tests were carried out with the strong positive ones allocated to observation group （n = 50） and the negative ones allocated to control group （n = 50）. Serum CRP concentrations were detected by immune rate nephelometry. The t＇-test, X2 test and spearman correlation analysis were used to analyze the relation between the CRP concentration and the average diameter of PPD - test. Results Serum CRP concentration in observation group was （ 3.00 ± 4. 53 ） mg/L , while （ 1.90 ± 1.77 ） mg/L in control group with no statistically significant difference（ t＇ = 1. 5993 ,P〉 0. 05 ）. The positive rate of CRP in the two groups were 8.00% and 2. 00% respectively （x2 = 0. 8421 ,P 〉 0. 05 ）. There was no relationship between the average diameter of PPD - test and the concentration of CRP in observation group（ r = 0. 160,P = 0. 134 ）. Conclusion Infection of mycobacterium tuberculosis do not lead to the CRP concentration increasing, therefore CRP is not a useful marker for infection of mycobacterium tuberculosis.