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EFFECTS OF DISULFIRAM AND THREE RELATED COMPOUNDS ON THE ACTIVITY OF ALCOHOL DEHYDROGENASE AND ALDEHYDE DEHYDROGENASE IN RAT LIVER AND GASTRIC MUCOSA |
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| Authors: | Y. Lamboeuf G. de Saint-Blanquat R. Derache |
| Affiliation: | Groupe de Recherches sur la Toxicologie des Aliments et des Boissons, Institut National de la Santéet de la Recherche Médicale, UniversitéPaul Sabatier, Toulouse, France |
| Abstract: | SUMMARY 1. Disulfiram or related compounds were administered to rats by stomach tube and the activities of alcohol dehydrogenase and aldehyde dehydrogenase in the liver and the gastric mucosa were determined 43 h later. 2. In liver, disulfiram did not affect alcohol dehydrogenase activity but reduced aldehyde dehydrogenase activity. The disulfiram metabolite diethyldithiocarbamate was without action. 3. In gastric mucosa, disulfiram had no effect on aldehyde dehydrogenase activity but enhanced alcohol dehydrogenase activity. Diethyldithiocarbamate had a similar effect. 4. The increase in alcohol dehydrogenase activity in the gastric mucosa might explain the hyperacetaldehydaemia produced by ethanol in disulfiram-treated patients. |
| Keywords: | alcohol dehydrogenase aldehyde dehydrogenase disulfiram ethanol metabolism gastric mucosa. |