Neutropénies allo-immunes néonatales. Intérêt du traitement par facteur de croissance granuleux (G-CSF). Deux nouvelles observations |
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| Authors: | A. B du, P. Rohrlich, C. Farnoux, M. Duval, O. Fenneteau, C. Boissinot, D. Pinquier, J. Cartron, E. Vilmer,Y. Aujard |
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| Affiliation: | 1Service de néonatologie, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France;2ETS AP-HP site transfusionnel, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France;3service d'hématologie pédiatrique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France;4service d'hématologie biologique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France;5service de gynécologie-obstétrique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France;6ETS AP-HP site transfusionnel, hôpital de Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France |
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| Abstract: | Alloimmune neonatal neutropenia is a rare event. Usually asymptomatic, it may however in some cases result in a severe sepsis. Treatment with recombinant granulocyte colony-stimulating factor (G-CSF) has been recently proposed.Case reportsWe report two new cases in infected newborns of a successful treatment of alloimmune neonatal neutropenia with G-CSF, resulting in complete neutrophil recovery in less than 72 hours. Moreover, the treatment was well tolerated.ConclusionThe analysis of these two cases and of those previously reported indicates that G-CSF represents the first-choice treatment in this affection when infectious signs are present in the neonate. |
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| Keywords: | G-CSF neutropé nieAuthor Keywords: infant newborn agranulocytosis immune complex disease G-CSF |
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