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| 茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用 | |
| 引用本文： | 洪宗元,郑青山,桂常青,宋建国,孙瑞元. 茶多酚对家兔阳离子化牛血清白蛋白肾炎模型的治疗作用[J]. 中国临床药理学与治疗学, 2002, 7(3): 217-220 |
| 作者姓名： | 洪宗元 郑青山 桂常青 宋建国 孙瑞元 |
| 作者单位： | 1. 中国科技大学生命科学学院,合肥 230027 2. 安徽省药物临床评价中心,芜湖,241001 3. 皖南医学院药理教研室,芜湖 241001 |
| 基金项目： | The project was supported by the Natural Scientific Foundation of Anhui Province (№ 98444332) and the Educational Foundation of Anhui Province (№ 98JL042). |
| 摘 要： | 目的 探讨茶多酚对家兔阳离子化牛血清白蛋白模型(C-BSA)肾炎的治疗作用. 方法 按文献方法复制家兔C-BSA肾小球肾炎模型,并用3种不同剂量的茶多酚 (30, 100 和 300 mg*kg-1) 给C-BSA肾小球肾炎模型兔灌胃,每日1次,连续 14 d. 结果 茶多酚不仅可以显著减少模型兔 24 h 尿蛋白分泌,降低血清肌酐和尿素氮水平,而且可以减轻肾小球病理损害,并且存在明显的量效关系. 结论 茶多酚对家兔C-BSA模型肾炎具有明显的治疗作用. |
| 关 键 词： | 茶多酚 治疗 阳离子化牛血清白蛋白肾小球肾炎 动物模型 C－BSA |
| 文章编号： | 1009-2501(2002)03-0217-04 |
| 修稿时间： | 2001-10-18 |
Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephiritis in rabbits |
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| HONG Zong Yuan,ZHENG Qing Shan ,GUI Chang Qing ,SONG Jian Guo ,SUN Rui Yuan. Therapeutic effect of tea polyphenols on cationic bovine serum albumin glomerulonephiritis in rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 217-220 | |
| Authors: | HONG Zong Yuan ZHENG Qing Shan GUI Chang Qing SONG Jian Guo SUN Rui Yuan |
| Affiliation: | HONG Zong Yuan,ZHENG Qing Shan 2,GUI Chang Qing 3,SONG Jian Guo 3,SUN Rui Yuan 2 |
| Abstract: | To investigate the therapeutic effect of tea polyphenols (TP) on cationic bovine serum albumin (C-BSA) glomerulonephritis. METHODS: C-BSA glomerulonephritic model was induced in rabbits. TP in three different doses (30, 100 and 300 mg·kg-1) was administered (ig) once daily for 14 days. RESULTS: TP not only significantly reduced the urinary protein excretion, decreased blood urea nitrogen (BUN) and plasma creatinine (Cr) levels, but also significantly relieved gloermular lesions in the rabbits treated and there was a significant dose-dependent relationship between high dosage (300 mg·kg-1) and low dosage (30 mg·kg-1). CONCLUSION: TP can reduce proteinuria, suppress the development of glomerular impairments， and ameliorate the kidney function of rabbits with C-BSA glomerulonephritis. |
| Keywords: | tea polyphenols C BSA glomerulonephritis rabbit animal model |
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