肺炎克雷伯菌耐亚胺培南的现状及机制

肺炎克雷伯菌（Klebsiella pneumoniae，KP）是临床常见的条件致病菌之一，广泛分布于医院环境中，常易导致呼吸道、泌尿道、腹腔感染以及血流感染。作为碳青霉烯类抗菌药物，亚胺培南对多药耐药的肺炎克雷伯菌所致感染具有很好的疗效。近年来，随着抗菌药物在临床的广泛使用甚至滥用，肺炎克雷伯菌对亚胺培南的耐药性也日趋严重，给临床抗感染治疗带来了更多的困难和挑战。本文就耐亚胺培南肺炎克雷伯菌耐药现状和耐药机制进行简要综述，以期为相关合理用药等提供参考。

Current status and mechanisms of imipenem resistant Klebsiella pneumoniae

Klebsiella pneumoniae is a common opportunistic pathogen, which is widely distributed in the hospital settings, and often causes infections in the respiratory tract, urinary tract, bloodstream and abdominal cavity. As a kind of carbapenems, imipenem has shown high antimicrobial activity against Klebsiella pneumoniae, especially multidrug-resistant Klebsiella pneumoniae. Recently, Imipenem resistant Klebsiella pneumoniae has been increasingly reported with the widespread use and abuse of antibiotics, causing more difficulties and challenges on clinical treatment. This review summarizes the current status and resistance mechanisms of imipenem resistant Klebsiella pneumoniae to provide an insight into rational use of drugs.