复方龙血竭口腔溃疡双层膜的研制

目的：研制剂型更适合治疗口腔溃疡的双层膜药物制剂。方法：通过预试验和L₉（3³）正交试验，筛选出适宜的口腔溃疡双层膜处方，用匀浆流延成膜法制成双层膜剂并进行相关指标的测定。结果：以2.5%乙基纤维素无水乙醇液作为空白隔离层，1.5%的壳聚糖和2.0%的明胶以1：1配比作为药膜层得到的双层膜剂，外观性状及性能良好。结论：该制备工艺简便、易行，可用作复方龙血竭口腔溃疡双层膜的制备。

Development of double-layer drug films of compound resina draconis against recurrent oral ulcer

OBJECTIVE To develop double-layer drug films of compound resina draconis for treating recurrent oral ulcer.METHODS According to previous researches and orthogonal experiments, optimal formulas were screened for drug layer and sealing-coat layer, then double-layer drug films were prepared and relevant parameters were measured.RESULTS Double-layer drug films were prepared with 2.5% ethylcellulose ethanol solution as the sealing-coat layer solution, and 1.5% chitosan and 2.0% gelatin water solution at a 1:1 ratio as the drug layer solution showed good appearance and performance.CONCLUSION The preparation technique is feasible and can be used for preparing double-layer drug films of compound resina draconis against oral ulcer.