| IgA肾病IgA1糖基化异常及相关中医药干预进展 |
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| 作者姓名： | 袁川 列才华 |
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| 作者单位： | 1. 830000 乌鲁木齐，新疆医科大学；新疆军区总医院肾脏内科
2. 新疆军区总医院肾脏内科 |
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| 基金项目： | 新疆维吾尔自治区自然基金面上项目资助(2015211C236) |
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| 摘 要： | IgA肾病是目前全球范围内最常见的原发性肾小球肾炎，病程进展快慢不一，临床表现多样，其中约10%～20%患者在10年内进展至终末期肾衰竭。IgA1异常糖基化与IgA肾病发病有着密切联系；减少异常糖基化IgA1可有效延缓IgA肾病的进展。对异常糖基化IgA1导致IgA肾病的病因机制、中医药对IgA肾病的治疗现况进行研究，有助于提供诊疗新途径、新思路。
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| 关 键 词： | IgA肾病 IgA1 异常糖基化 发病机制 中医药 |
| 收稿时间： | 2018-02-05 |
Progress in research on IgA1 glycosylation abnormality and intervention by traditional Chinese medicine in IgA nephropathy |
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| Authors: | Chuan Yuan Caihua Lie |
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| Institution: | 1. Xinjiang Medical University, General Hospital of Xinjiang Military Command; Department of Nephrology, General Hospital of Xinjiang Military Command; Urumqi 830000, Xinjiang, China
2. Department of Nephrology, General Hospital of Xinjiang Military Command; Urumqi 830000, Xinjiang, China |
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| Abstract: | IgA nephropathy (IgAN) is the most common primary glomerulonephritis all over the world. The progression of the disease is different, and the clinical manifestations are diverse. About 10%-20% IgAN patients progress to end-stage renal failure within 10 years. Abnormal glycosylation of IgA1 is closely related to the pathogenesis of IgAN. Reducing abnormal glycosylation of IgA1 can effectively delay the progression of IgAN. Studying the pathogenesis of IgAN caused by abnormal glycosylation of IgA1 and the current status of treatment of IgAN by traditional Chinese medicine, is helpful for providing new ways and new ideas in diagnosis and treatment of IgAN. |
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| Keywords: | IgA nephropathy IgA1 Abnormal glycosylation Pathogenesis Traditional Chinese medicine |
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