预注硬化剂减少组织胶治疗后胃静脉曲张早期排胶出血

目的通过先注射硬化剂、再注射组织胶的方法治疗胃静脉曲张，观察是否能降低早期排胶出血率。 方法回顾性分析2014年1月至2018年3月经解放军火箭军总医院消化内镜中心因食管胃静脉曲张接受内镜下组织胶注射治疗的274例患者，将患者分成二组：改良方法组(组织胶注射灌注硬化剂)14例；传统方法组(单纯注射组织胶)133例。改良方法组注射组织胶前预注硬化剂3～5 ml。观察两组早期排胶再出血发生情况的差异。 结果传统方法组133例患者中发生早期排胶再出血9例，再出血率6.8%；改良方法组141例患者中发生早期排胶再出血2例，再出血率1.4%，较传统方法再出血率降低(P＝0.031)。 结论在胃静脉曲张患者内镜治疗中，改良方法组预注硬化剂比传统方法组织胶注射治疗具有更低的早期排胶再出血率。

Pre-injection of lauromacrogol decreases rebleeding due to cyanoacrylate extrusion after cyanoacrylate injection of gastric varices

ObjectiveThe rate of early rebleeding was evaluated due to early cyanoacrylate extrusion after pre-injection of lauromacrogol before cyanoacrylate injection for treating gastric varices. MethodA total of 274 patients admitted to the digestive endoscopic center of PLA Rocket Force General Hospital for gastric varices between January 2014 and March 2018 were enrolled into two treatment groups: lauromacrogol-cyanoacrylate group and cyanoacrylate group. Patients were followed up to observe early rebleeding due to cyanoacrylate extrusion. ResultsIn the cyanoacylate group, 9 of 133 patients developed rebleeding due to cyanoacrylate extrusion, the rebleeding rate was 6.8%.While in the lauromacrogol- cyanoacrylate group, only 2 of 144 patients developed rebleeding due to cyanoacrylate extrusion, the rebleeding rate was 1.4%, lower than that of cyanoacrylate group (P=0.031). ConclusionIn this study, it was demonstrated that pretreated with lauromacrogol before cyanoacrylate injection can significantly decrease the rebleeding rate due to cyanoacrylate extrusion.