酸敏感受体与心理因素在胃食管反流病内脏高敏感产生的作用研究

胃食管反流病（GERD）是一类常见的消化道良性疾病，通常以烧心和反酸为典型症状出现。临床上以质子泵抑制剂做为首选药物控制GERD患者的症状，但部分患者治疗效果并不理想。目前认为，食管内脏高敏感（VH）是GERD关键的发病机制之一，成为了近年来的研究热点。VH表现为低阈值刺激即可引起的相对强烈的反应或不适，本文从酸敏感受体和心理因素的角度对GERD内脏高敏感产生中的作用做一综述。

Effects of acid sensitive receptors and psychological factors in the mechanism of visceral hypersensitivity in gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is a common gastrointestinal benign disease, which can be characterized by typical symptoms such as heartburn and regurgitation. Clinically, symptoms of GERD patients can be controlled by proton pump inhibitors (PPIs) , but the consequence after the treatment is unsatisfactory in some patients. According to recent studies, visceral hypersensitivity (VH), which caused by low threshold stimulus and results in strong reaction or discomfort, plays a key role in the pathogenesis of GERD. Here we briefly reviewed the effects of acid sensitive receptors and psychological factors in the mechanism of visceral hypersensitivity in GERD.