药动学-药效学模型在临床合理用药的应用价值分析

药动学-药效学（pharmacokinetics-pharmacodynamics，PK-PD）结合模型阐明了时间-药物浓度-效应三者间关系，能较全面地分析和预测特定给药方案下，药物效应随时间的变化情况，对新药研发，药物临床试验及临床合理用药具有重要的参考价值。现从给药方案优化，疗效和不良反应预测，相互作用分析等方面对近年来国内外PK-PD指导临床用药情况进行综述，阐明PK-PD模型对药物合理使用的意义。

Value of pharmacokinetics-pharmacodynamics model in rational drug use

Pharmacokinetics-pharmacodynamics (PK-PD) combined model explained the relationship of time-effect-drug concentration in mathematical formula, which could comprehensively analyze and predict a time-response relationship in a certain dosage regimen. PK-PD model valued crucially in drug discovery, clinical trails and rational drug use. This paper analyzed the significance of PK-PD model in medication at home and abroad in recent years, concluding dosage regimen optimizing, predicting efficacy or adverse reactions and drug interactions. More importantly, the value of PK-PD model in rational drug use was well demonstrated.