Increased Risk of Thai Childhood Acute Lymphoblastic Leukemia with the MiR196a2 T>C Polymorphism |
| |
Authors: | Sarinthorn RakmaneeSamart PakakasamaSuradej HongengSirima SanguansinAcharawan ThongmeeWanida Pongstaporn |
| |
Institution: | 1Department of Biomedical Science, Faculty of Science, Rangsit University, Pathumthani, Thailand.2Hematology unit, Pediatric departments, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.3Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.4Microbiology unit, Department of Biomedical Science, Faculty of Science, Rangsit University, Pathumthani, Thailand. |
| |
Abstract: | Objectives: This study assessed associations of the miR196a2 (rs11614913) T>C polymorphism withsusceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Blood DNA samples from 104 childhood ALL patients and 180 healthy children were studied for the miR-196a2 (rs11614913) polymorphism using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) approach. Results: The frequency of the miR-196a2 (rs11614913) T allele in controls was 0.51 compared with 0.33 in ALL cases. In this study, CC, TC heterozygote and CC/TC genotypes were significantly associated with increase childhood ALL susceptibility compared with the TT wild type (OR =4.321, 95% CI = 2.091-8.930 p=0.000, OR = 2.248, 95% CI =1.103-4.579, p=0.024, OR = 2.921, 95% CI = 1.504-5.673 p=0.001, respectively). However, the miR-196a2 (rs11614913) T>C polymorphism was not associated with demographic data or clinico-pathological data in ALL cases. Conclusion: CC, TC and CC+TC genotypes of miR-196a2 (rs11614913) was significantly associated with increased susceptibility in Thai childhood ALL but not with clinical variables. |
| |
Keywords: | Acute Lymphoblastic Leukemia miRNA-196a2 Polymorphism |
|
| 点击此处可从《Asian Pacific journal of cancer prevention : APJCP》浏览原始摘要信息 |
| 点击此处可从《Asian Pacific journal of cancer prevention : APJCP》下载免费的PDF全文 |
|