| 单壁碳纳米管-异甘草素复合物在大鼠体内缓释性能的研究 |
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| 引用本文： | 范玉涵,姚瑛,马全武,周彦华.单壁碳纳米管-异甘草素复合物在大鼠体内缓释性能的研究[J].中国医院药学杂志,2017,37(4):325-327,332. |
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| 作者姓名： | 范玉涵 姚瑛 马全武 周彦华 |
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| 作者单位： | 1. 宁夏医科大学总医院, 宁夏 银川 750004;
2. 宁夏人民医院, 宁夏 银川 750004 |
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| 基金项目： | 宁夏医科大学青年基金项目（编号：XQ2013027） |
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| 摘 要： | 目的：研究单壁碳纳米管（SWNTs）-异甘草素复合物在大鼠体内的缓释性能。方法：以大鼠为动物模型，将碳纳米管-异甘草素复合物以聚乙二醇400稀释液分散灌胃，不同时间点取血，以高效液相色谱法测定血浆中异甘草素浓度，探讨复合物的体内缓释性能。结果：单壁碳纳米管-异甘草素复合物在大鼠体内具有明显缓释作用，tmax和Cmax分别为11.2 h和201.3 ng·mL-1，相对于异甘草素组的相对生物利用度为141.8%。结论：单壁碳纳米管具有良好的缓释性能，具有作为缓释载体材料的潜力。
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| 关 键 词： | 单壁碳纳米管 异甘草素 体内 缓释 |
| 收稿时间： | 2016-03-01 |
Sustained release of single-wall carbon nanotube and isoliquiritigen complex in rats |
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| FAN Yu-han,YAO Ying,MA Quan-wu,ZHOU Yan-hua.Sustained release of single-wall carbon nanotube and isoliquiritigen complex in rats[J].Chinese Journal of Hospital Pharmacy,2017,37(4):325-327,332. |
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| Authors: | FAN Yu-han YAO Ying MA Quan-wu ZHOU Yan-hua |
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| Institution: | 1. General Hospital of Ningxia Medical University Ningxia Yinchuan 750004, China;
2. Ningxia People's hospital, Ningxia Yinchuan 750004, China |
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| Abstract: | OBJECTIVE To investigate the sustained-release effect about single-wall carbon nanotube (SWNTs)-isoliquiritigen (ISL) complex in rats.METHODS SWNTs-ISL diluted by polyglycol 400 was used to fill rat stomachs. Plasma samples were obtained at different time points, and high performance liquid chromatography (HPLC) was used to determine drug level of ISL in blood.RESULTS SWNTs-ISL had significantly sustained release in rats, and the corresponding tmax and Cmax were 11.2 h and 201.3 ng·mL-1, respectively. Its bioavailability was 141.8% compared to pure ISL.CONCLUSION SWNTs have better sustained release and it is a material with great potential of sustained-release. |
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| Keywords: | single-wall carbon nanotubes isoliquiritigenin in vivo sustained release |
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