肥胖患者睡眠呼吸暂停综合征与胃食管反流病相关性研究

目的探讨肥胖患者呼吸睡眠暂停综合征（OSAS）与胃食管反流病（GERD）的相关性。 方法选取2015年3月至2016年4月，新疆维吾尔自治区人民医院肥胖93例患者临床资料，对其进行肺功能、肺容积测定、夜间睡眠监测、食管测压和24 h全食管测酸等检查，根据其睡眠监测结果分为OSAS组和非OSAS组，比较2组患者睡眠呼吸暂停低通气指数（AHI）与食管功能学指标相关性。 结果在非OSAS和OSAS组患者中，食管反流的百分比和胃-食管压力差与其AHI呈正相关（P<0.05 ）；吸呼气压力差、食管下括约肌（LES）静息压与其AHI呈负相关（P<0.05 ）。 结论肥胖患者中OSAS与GERD之间有着密切关系，并互为因果，可相互影响、加重。

Study on the correlation between sleep apnea syndrome and gastroesophageal reflux disease in obesity patients

ObjectiveTo investigate the correlation between OSAS and GERD in obese patients. MethodsRetrospective analysis of clinical data of patients with obesity in the Xinjiang Uygur Autonomous Region people's Hospital from March 2015 to April 2016, perfact of pulmonary function、lung volume determination、sleeping monitoring, esophageal manometry, which according to the sleeping monitoring the results were divided into OSAS and non-OSAS group. Studying on the correlation between AHI and esophageal function. ResultsIn the non-OSAS and OSAS group, the percentage of reflux correlation with AHI the (P=0.005), stomach-esophageal pressure difference and AHI was positively correlated (P<0.05); Disparity expiratory pressure and LES negative correlation with AHI (P<0.05). ConclusionThere is a closely relationship between OSAS and GERD in obese patients, and they are reciprocal causation, which can influence each other and aggravate each other.