药学干预对缺血性脑卒中患者二级预防用药依从性的影响

目的：评价药学干预措施对缺血性脑卒中患者二级预防用药依从性的影响。方法：将某院神经内科收住的418例缺血性脑卒中患者分为干预组和对照组,干预组配备专科临床药师,实施个体化给药、开展床旁用药宣教、发放患者出院用药指导单,对照组不予干预。制定二级预防用药知识和用药依从性调查表,在出院时对2组患者进行用药知识调查,在出院3个月后对2组患者行电话回访进行用药依从性调查。结果：在二级预防用药知识方面,干预组回答为优的比例明显高于对照组,差异有高度统计学意义（P<0.01）。依从性方面干预组明显优于对照组,差异有统计学意义（P<0.05）。结论：临床药师对缺血性脑卒中患者进行药学干预可以增加患者的用药知识、提高二级预防用药依从性。

The effects of pharmaceutical intervention on compliance with secondary prophylactic medication among patients with ischemic stroke

OBJECTIVE To evaluate the effects of pharmaceutical intervention on compliance with secondary prophylactic medication among patients with ischemic stroke. METHODS Patients with ischemic stroke admitted to Neurology Department of our hospital were randomized into the intervention group and control group. In the intervention group, clinical pharmacists were assigned, individualized medication was implemented, bedside medication education was provided, and patient instructions on post discharge medication was dispensed, while no intervention was provided in the control group. A questionnaire was formulated on the knowledge of and compliance with secondary prophylactic medication for a survey at discharge among patients in both groups, and the medication compliance among patients in both groups was investigated via telephone follow-up at 3 months post discharge. RESULTS With regard to the knowledge on secondary prophylactic medication, a significantly higher proportion of patients in the intervention group gave an "excellent" answer than in the control group, with statistically significant difference (P<0.01). Medication compliance was significantly better in the intervention group than in the control group (P<0.05). CONCLUSION Pharmaceutical intervention can increase knowledge on medication and raise compliance with secondary prophylactic medication among patients with ischemic stroke.