前列地尔联合丁苯酞对老年2型糖尿病合并认知功能障碍的疗效观察

目的：观察前列地尔联合丁苯酞治疗老年2型糖尿病合并认知功能障碍的治疗效果，为2型糖尿病合并认知功能障碍老年患者的临床治疗提供帮助。方法：选取临床收治的2型糖尿病合并认知功能障碍老年患者100例，按随机数字表法分为：观察组（50例）和对照组（50例），对照组老年患者给予常规治疗，在此基础上，观察组老年患者给予丁苯酞和前列地尔的联合治疗，检测治疗前后2组老年患者MoCA评分、血小板参数、血液动力学及神经因子的变化。结果：与治疗前相比，2组老年患者神经因子（S-100β和NSE）、血小板参数（PDW、MPV、PLCR和PCT）和R1显著降低，MoCA评分、神经因子（NGF和NTF）和血液动力学指标（v_max、v_min和Q）显著升高，差异存在统计学意义（P<0.05）。经过联合治疗后观察组老年患者MoCA评分、神经因子（NGF和NTF）和血液动力学指标（v_max、v_min和Q）显著高于治疗后对照组，神经因子（S-100β和NSE）、血小板参数（PDW、MPV、PLCR和PCT）和R1显著低于治疗后对照组，差异存在统计学意义（P<0.05）。结论：丁苯酞和前列地尔的联合治疗能够改善2型糖尿病合并认知功能障碍老年患者的血小板状况，提高患者的MoCA 评分和神经机能同时加速血液流动，对2型糖尿病合并认知功能障碍老年患者的临床治疗具有重要的意义。

Efficacy of alprostadil combined with butylphthalide against cognitive dysfunction in elderly patients with type 2 diabetes mellitus

OBJECTIVE To observe efficacy of alprostadil combined with butylphthalide against cognitive dysfunction in elderly patients with type 2 diabetes mellitus,and provide a reference for therapy in patients with type 2 diabetes mellitus and cognitive dysfunction.METHODS Totally 100 elderly patients with type 2 diabetes mellitus and cognitive dysfunction were selected and randomly divided into groups:research group (50 patients) and control group (50 patients).Patients in control group were treated with basic treatment and the patients in the research group were treated with alprostadil combined with butylphthalide.Platelet parameters,MoCA score,hemodynamics and nerve factors were compared before and after therapy,and the acting mechanism was analyzed.RESULTS Before treatment,MoCA score,platelet parameters,hemodynamics and nerve factor showed no significant difference between two groups.After treatment,R1,platelet parameters (BVH,BVM,BVL,FIB,and PCV) and nerve factors (S-100β,and NSE) decreased significantly (P<0.05),while MoCA score,nerve factors (NGF and NTF) and hemodynamics (v_max,v_min and Q) increased significantly (P<0.05).Compared to control group,after treatment,MoCA score,IL-2 and oxidative stress index (GSH-Px,CAT,and SOD) increased significantly (P<0.05),R1,platelet parameters (BVH,BVM,BVL,FIB,and PCV) and nerve factors (S-100β,and NSE) decreased significantly (P<0.05) in research group.CONCLUSION Alprostadil combined with butylphthalide can improve neurological functions,increase MoCA score,promote platelet status,and accelerate blood flow.The combination therapy has important clinical significance for elderly patients with type 2 diabetes mellitus and cognitive dysfunction.