| 急性高原低氧对于大鼠血红蛋白和血浆miR－144表达影响的研究 |
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| 引用本文： | 冯振龙,施冰,赵永岐,朱玲玲,李俊峡. 急性高原低氧对于大鼠血红蛋白和血浆miR－144表达影响的研究[J]. 中华心脏与心律电子杂志, 2018, 6(4): 195-198. DOI: 10.3877/cma.j.issn.2095-6568.2018.04.002 |
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| 作者姓名： | 冯振龙 施冰 赵永岐 朱玲玲 李俊峡 |
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| 作者单位： | 1. 100700 北京，中国人民解放军陆军总医院；230031 合肥，安徽医科大学研究生院2. 100850 北京，军事医学科学院基础医学研究所3. 230031 合肥，安徽医科大学研究生院 |
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| 基金项目： | 全军后勤重点课题资助项目(BBJ14L001) |
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| 摘 要： | 目的探讨急性高原低氧对于大鼠血红蛋白和血浆miR－144表达的影响。 方法应用低压氧舱构建高原低氧大鼠模型，分为高原低氧暴露3、7、14、28 d实验组以及常压常氧对照组。检测各组大鼠血常规和血浆miR－144表达情况。 结果与对照组比较，低压低氧组大鼠血浆miR－144、红细胞计数、血红蛋白含量均随高原低氧时间延长而显著升高(P<0.05)。Spearman相关性分析提示血浆miR－144与红细胞计数、血红蛋白含量呈正相关。 结论急性高原低氧可使大鼠血红蛋白和血浆miR－144表达升高。血浆miR－144可能参与调控高原低氧相关的红系变化。
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| 关 键 词： | 高原 低压低氧 miR－144 红细胞增多症 |
| 收稿时间： | 2018-06-20 |
Effect of acute hypobaric hypoxia at high altitude on the expression of hemoglobin and miR-144 in plasma in rats |
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| Zhenglong Feng,Bing Shi,Yongqi Zhao,Lingling Zhu,Junxia Li. Effect of acute hypobaric hypoxia at high altitude on the expression of hemoglobin and miR-144 in plasma in rats[J]. Chinese Journal of Heart and Heart Rhythm, 2018, 6(4): 195-198. DOI: 10.3877/cma.j.issn.2095-6568.2018.04.002 |
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| Authors: | Zhenglong Feng Bing Shi Yongqi Zhao Lingling Zhu Junxia Li |
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| Affiliation: | 1. Department of Cardiology, PLA Army General Hospital, Beijing 100700, China; Graduate School, Anhui Medical University, Hefei 230031, China2. the Institute of Basic Medical Sciences, Academy of Military Medical Science, Beijing 100850, China3. Department of Cardiology, PLA Army General Hospital, Beijing 100700, China |
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| Abstract: | ObjectiveThis study investigated the effect of acute hypobaric hypoxia at high altitude on the expression of hemoglobin and miR-144 in plasma in rats. MethodsAdult male Sprague-Dawley rats were randomly assigned to a normoxic group and four hypoxic groups. Rats in hypoxic groups were exposed to simulated hypobaric hypoxia chamber equivalent to 7 000 meters for different durations (3, 7, 14 and 28 days). Subsequently, blood routine test and the expression of miR-144 in plasma were measured in each group. ResultsCompared with the normoxic group, the expression of miR-144, erythrocyte count and hemoglobin in four hypoxic groups increased significantly (P<0.05). Spearman correlation analysis showed that the expression of miR-144 in plasma was positively correlated with erythrocyte count and hemoglobin. ConclusionAcute hypobaric hypoxia at high altitude increased the expression of miR-144 in plasma and hemoglobin. It is predicted that miR-144 in plasma could induce polycythemia related to hypobaric hypoxia at high altitude. Regulations on miR-144 expression had a great value in clinical application. |
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| Keywords: | High altitude Hypobaric hypoxia miR-144 Polycythemia |
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