| 壳聚糖-β-环糊精药物载体的制备与表征 |
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| 引用本文： | 李海浪,叶廷秀,余亚选,纪美茹,林志强.壳聚糖-β-环糊精药物载体的制备与表征[J].中国医院药学杂志,2017,37(4):341-343,355. |
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| 作者姓名： | 李海浪 叶廷秀 余亚选 纪美茹 林志强 |
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| 作者单位： | 1. 厦门医学高等专科学校, 福建 厦门 363000;
2. 福建医科大学附属泉州第一医院药剂科, 福建 泉州 362000 |
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| 基金项目： | 厦门医学高等专科学校科研项目（编号：Z2014-06） |
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| 摘 要： | 目的：制备壳聚糖-β-环糊精药物载体，以期开发β-环糊精在疏水性药物缓释制剂方面的潜在应用价值。方法：采用共价键使壳聚糖与β-环糊精偶联，利用红外光谱（IR）、核磁共振氢谱（1H-NMR）以及X-射线衍射（X-RD）对偶合物进行表征，运用元素分析法对偶合物中的β-环糊精进行定量。结果：壳聚糖与β-环糊精成功偶联，β-环糊精取代度为13%。结论：通过亲核取代反应，可以成功将β-环糊精嫁接到壳聚糖分子上。
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| 关 键 词： | 壳聚糖 β-环糊精 药物载体 |
| 收稿时间： | 2016-03-03 |
Preparation and characterization of chitosan-grafted-β-cyclodextrin |
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| LI Hai-lang,YE Ting-xiu,YU Ya-xuan,JI Mei-ru,LIN Zhi-qiang.Preparation and characterization of chitosan-grafted-β-cyclodextrin[J].Chinese Journal of Hospital Pharmacy,2017,37(4):341-343,355. |
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| Authors: | LI Hai-lang YE Ting-xiu YU Ya-xuan JI Mei-ru LIN Zhi-qiang |
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| Institution: | 1. Xiamen Medical College, Fujian Xiamen 363000, China;
2. Department of Pharmacy, Quanzhou First Hospital Affiliated to Fujian Medical University, Fujian Quanzhou 362000, China |
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| Abstract: | OBJECTIVE To prepare chitosan-grafted-β-cyclodextrin compounds and exploit the potential of β-cyclodextrin in sustained-release preparation of hydrophobic drugs.METHODS Chitosan was linked to β-cyclodextrin by covalent bond. Obtained product were characterized by IR, 1H-NMR and X-RD and quantified by elemental analysis.RESULTS Chitosan was linked to β-cyclodextrin successfully and the substituting degree of β-cyclodextrin was 13%.CONCLUSION β-cyclodextrin can be grafted successfully to chitosan by nucleophilic substitution reaction. |
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| Keywords: | chitosan β-cyclodextrin drug carrier |
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