| 平阳霉素壳聚糖温敏原位凝胶的制备及体外评价 |
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| 引用本文： | 陈奋,贾连群,秦兴军,潘卫三.平阳霉素壳聚糖温敏原位凝胶的制备及体外评价[J].中国医院药学杂志,2017,37(9):792-796. |
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| 作者姓名： | 陈奋 贾连群 秦兴军 潘卫三 |
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| 作者单位： | 1. 辽宁中医药大学, 辽宁 沈阳 110847;
2. 上海交通大学医学院附属第九人民医院, 上海 200011;
3. 沈阳药科大学药学院, 辽宁 沈阳 110016 |
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| 基金项目： | 辽宁省科学技术计划项目（编号：2010225034）；辽宁省科技厅博士科研启动基金项目（编号：201601186） |
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| 摘 要： | 目的：制备平阳霉素壳聚糖温度敏感型原位凝胶，并进行流变学性质研究及体外评价。方法：采用流变仪考察平阳霉素原位凝胶体系的流变学性质。通过体外释放及体外降解研究，对制剂进行体外评价。结果：流变学研究表明，随着温度升高到37℃左右时，原位凝胶溶液发生了从溶液向凝胶的相转变过程。体外释药的研究表明，药物能持续释放10 d以上，累积释放量达到85%以上。结论：以上结果表明平阳霉素原位凝胶符合介入栓塞要求，体外具有明显缓释效果。
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| 关 键 词： | 平阳霉素 壳聚糖 温敏原位凝胶 流变学 体外评价 |
| 收稿时间： | 2016-08-29 |
Preparation and in vitro evaluation of Pingyangmycin loaded chitosan thermogels |
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| CHEN Fen,JIA Lian-qun,QIN Xing-jun,PAN Wei-san.Preparation and in vitro evaluation of Pingyangmycin loaded chitosan thermogels[J].Chinese Journal of Hospital Pharmacy,2017,37(9):792-796. |
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| Authors: | CHEN Fen JIA Lian-qun QIN Xing-jun PAN Wei-san |
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| Institution: | 1. Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang 100847, China;
2. Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China;
3. School of Pharmacy, Shenyang Pharmaceutical University, Liaoning Shenyang 110016, China |
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| Abstract: | OBJECTIVE To prepare pingyangmycin-loaded chitosan thermogels and study the rheological properties, in vitro release behaviors and in vitro degradation.METHODS Rheometer was used to investigate rheological properties of pingyangmycin thermogels. In vitro release and in vitro degradation were studied for evaluation of pingyangmycin thermogels.RESULTS As the temperature raised to 37℃, pingyangmycin thermogels would transform from liquid phase to gel phase. In vitro release studies indicated that pingyangmycin could slowly release for more than 10 days, and the cumulative release quantity could be up to 85%.CONCLUSION Pingyangmycin thermogels can meet the embolism requirements and have extended release effects in vitro. |
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| Keywords: | pingyangmycin chitosan thermogel rheology in vitro evaluation |
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