3种益生菌制剂联合美沙拉秦口服治疗轻中度溃疡性结肠炎疗效

 目的 观察双歧杆菌四联活菌片、酪酸梭菌活菌散剂、布拉酵母菌散联合美沙拉秦缓释颗粒治疗轻、中度溃疡性结肠炎(ulcerative colitis,UC)的临床疗效。方法 将我院2014-01至2016-12收治的160例轻、中度UC患者,随机分为4组,其中3个对照组、1个治疗组,每组40例。每个对照组口服2种益生菌制剂(组间不全相同)及美沙拉秦缓释颗粒,治疗组口服3种益生菌制剂及美沙拉秦缓释颗粒,疗程均为4周。比较治疗组与对照组的Mayo活动指数评分、粪便钙卫蛋白(fecal calprotectin,FC)值、结肠镜下评分、胃肠生活质量评分(gastrointestinal quality of life index,GIQLI)及临床疗效。结果 治疗后治疗组Mayo活动指数评分下降为1.43±0.86,FC值下降为135.33±95.53,结肠镜下评分下降为2.17±1.21,GIQLI升高为114.33±13.51,治疗组与任何一个对照组上述指标比较差异均有统计学意义(P<0.05),治疗组及每个对照组在治疗前、后的比较差异均有统计学意义(P<0.05),对照组之间比较差异均无统计学意义。结论 双歧杆菌四联活菌片、酪酸梭菌活菌散剂、布拉酵母菌散联合美沙拉秦缓释颗粒口服治疗轻、中度UC疗效确切,安全可靠。

Clinical effect of three probiotic agents combined with Mesalazine in treatment of mild or moderate ulcerative colitis

Objective To observe the therapeutic effect of Bifidobacterium tetravaccine Tablets(live), Clostridium butyricum powder, Saccharomyces boulardii sachets combined with Mesalazine SR granules on mild or moderate ulcerative colitis.Methods A total of 160 patients who had been treated between January 2014 and December 2016 were randomly divided into the trail group and three control groups(40 patients in each group). Each of the control groups took two types of probiotic agents (not the same type between the three control groups) and Mesalazine SR granules, while the trail group took the three types of probiotic agents and Mesalazine SR granules. The therapy lasted 4 weeks. Mayo activity index scores, fecal calprotectin values, colonoscopy scores, gastrointestinal quality of life indexes and clinical effect were compared between the trail group and control group.Results After treatment, the Mayo activity index score in the trail group was reduced to 1.43±; 0.86, fecal calprotectin value to 135.33±; 95.53, colonoscopy score to 2.17±; 1.21, while the gastrointestinal quality of life index was elevated to 114.33±; 13.51. There was statistically significant difference (P<; 0.05) between the trail group and each control group in the above indicators. The changes were also statistically significant after treatment in each group (P<; 0.05), but there was not statistically significant difference between the control groups. There was some correlation between the Mayo score and fecal calprotectin levels.Conclusions Bifidobacterium tetravaccine Tablets(live), Clostridium butyricum powder, Saccharomyces boulardii sachets combined with Mesalazine SR granules are effective and safe for mild or moderate ulcerative colitis.