Role of senescence induction in cancer treatment |
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Authors: | Shenghui Qin Bradley A Schulte Gavin Y Wang |
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Institution: | Shenghui Qin, Bradley A Schulte, Gavin Y Wang, Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, United StatesGavin Y Wang, Developmental Cancer Therapeutics Program of Hollings Cancer Center, Charleston, SC 29425, United States |
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Abstract: | Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening, DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types, suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment. |
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Keywords: | Cellular senescence Cancer treatment Chemotherapy Ionizing radiation Cyclin-dependent kinases 4/6 inhibitor Aurora kinase inhibitor Immunotherapy T helper-1 cells T helper-1 cytokines |
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