DNA倍体分析联合宫颈液基细胞学检查在宫颈癌筛查中的应用

目的 探讨宫颈液基细胞学检查和宫颈DNA倍体分析在宫颈癌筛查中的意义。方法 对18207例宫颈癌筛查人员进行宫颈液基细胞学检查和/或宫颈DNA倍体分析,并与宫颈活检结果对比分析。结果 TCT报告14378例,DNA倍体分析5932例,两者方法联合应用的有2104例。TCT检查中以ASC-US/AGC为切入点,DNA检查中以可见少量DNA倍体异常细胞为切入点,两种方法诊断宫颈上皮内瘤变的敏感性分别为81.6%、85.3%,联合使用两种方法检查对宫颈上皮内瘤变的敏感性为98.1%。结论 两种方法联合应用,对于宫颈癌的定期筛查和宫颈癌的早诊早治有应用价值。

Application of DNA ploidy analysis and Liquid-based cytology in cervical cancer screening

Objective The Objectives of this study were to investigate the significance of DNA ploidy Analysis and Liquid-based cytology in cervical cancer screening. Methods 18207 cases of cervical cancer screening for cervical liquid based cytology times and/or cervical DNA analysis,and comparative analysis with cervical biopsy. Results TCT reports 14378 cases,DNA time's analysis of 5932 cases,combined with 2104 cases of the two Methods. TCT examination to ASC-US/AGC as the breakthrough point,abnormal DNA examination times visible with a small amount of DNA in the body cells as the breakthrough point,the two Methods in the diagnosis of cervical intraepithelial neoplasia sensitivity 81.6%,85.3% respectively,a combination of two Methods of examination of cervical intraepithelial neoplasia sensitivity was 98.1%. Conclusion Combined use of two Methods or cervical cancer screening and early detection of cervical cancer regularly treated early with application value.