The extrathymic T-cell development pathway. |
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| Authors: | B Rocha P Vassalli D Guy-Grand |
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| Affiliation: | 1. Benedita Rocha is at the Institut National de la Santé et de la Recherche Médicale, Unité 345, Switzerland;2. Delphine Guy-Grand at Unité 132, Hôpital Necker, 156 rue de Vaugirard, 75015 Paris, France;3. Pierre Vassalli is at the Dépt de Pathologie, Centre Medical Universitaire, CH 1211 Genève 4, Switzerland;1. Department of Radiation Oncology, Emory University, Atlanta, Georgia, USA;2. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA;3. Department of Winship Cancer Institute, Emory University, Atlanta, Georgia, USA;1. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;1. Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, Brazil;2. Departamento de Biologia Molecular, Universidade Federal de São Paulo, Brazil;3. Disciplina de Parasitologia Departamento de Microbiologia, Imunologia e Parasitologia Universidade Federal de São Paulo, Brazil;1. Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, University of Brasilia, Brasilia, 70919-970, Brazil;2. Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, Brazil;1. Division of General Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States;2. Division of Emergency Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States;3. PolicyLab, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States;4. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, United States |
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| Abstract: | In normal mice, not all T-lineage cells are generated and selected in the thymus; an alternative, extrathymic, development pathway exists. Extrathymic T cells are rare in the spleen and lymph nodes, but are abundant in some tissues, such as the gut. Here, Benedita Rocha, Pierre Vassalli and Delphine Guy-Grand discuss the rules of selection of extrathymic T cells, assess the possible role of these cells in the defence of epithelial integrity and their potential role in autoimmune disease. |
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