| 药物诱发小鼠生殖细胞及早期胚胎非整倍体的研究 |
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| 引用本文： | 张忠恕,王仁礼,沈启芳. 药物诱发小鼠生殖细胞及早期胚胎非整倍体的研究[J]. 生殖与避孕, 1992, 0(6) |
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| 作者姓名： | 张忠恕 王仁礼 沈启芳 |
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| 作者单位： | 上海市计划生育科学研究所(张忠恕，王仁礼)，上海市计划生育科学研究所(沈启芳) |
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| 摘 要： | 本文用超排卵技术使雌性小鼠排卵,排卵前用药物或化学物处理后与雄性小鼠交配,以小鼠卵母细胞(MⅡ)及第一次分裂合子雌原核染色体非整倍体及结构畸变为指标,研究其诱变作用。结果表明,对照组小鼠卵母细胞(MⅡ)及第一次分裂合子均未发现有染色体非整倍体及结构畸变。处理组中,环磷酰胺和乙醇可诱发小鼠卵母细胞(MⅡ)及第一次分裂合于雌原核染色体非整倍体率增加,醋酸棉酚、氯氮平、苯妥英钠及安定则无明显影响。
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| 关 键 词： | 药物 小鼠 卵母细胞 合子 染色体畸变 染色体不分离 |
Research on Aneuploidy Induced by Drugs in Germ Cells and Early Embryos of Mice |
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| Zhang Zhong-shu Wang Ren-li Shen Qi-fang. Research on Aneuploidy Induced by Drugs in Germ Cells and Early Embryos of Mice[J]. Reproduction and Contraception, 1992, 0(6) |
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| Authors: | Zhang Zhong-shu Wang Ren-li Shen Qi-fang |
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| Affiliation: | Shanghai Institute of Planned Parenthood Research |
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| Abstract: | In this research ICR female mice were stimulated to ovulate by the superovulation technique. Before ovulation, the female mice were treated with drugs and chemicals and then mated with male ones. The mutation-inducing effects of the drugs and chemicals were studied in terms of aneuploidy and chromosome aberrations in oocytes (MII) and female pronucleus of the first-cleavage zygotes.The results showed that no aneuploidy or chromosome aberration was found in the oocytes (MII) and first-cleavage zygotes in the mice of the control group. In the treated group, cyclophosphamide and ethanol induced an increased percentage of aneuploidy in the oocytes (MII) and female pronucleus of the first-cleavage zygotes, while gossypol acetate, clozapine, phenytoin and diazepam exerted no such influence. |
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| Keywords: | Drug Mouse Oocyte Zygote Chromosome aberration Chromosome nondisjunction |
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