TEG检测老年冠心病患者阿司匹林抵抗相关因素的研究

目的利用血栓弹力图检测老年冠心病患者阿司匹林抵抗的发生率，并探讨与之相关的影响因素。方法选取2012年1—6月老年冠心病患者245例，常规服用阿司匹林100mg至少≥30d，血栓弹力图法检测血小板聚集功能，同时用流式细胞仪检测血小板活化指标CD62p、CD63、GPⅡb／Ⅲa水平，并进行生化、同型半胱氨酸、CRP等相关检测。结果用血栓弹力图检测阿司匹林抵抗，阿司匹林抵抗组较阿司匹林敏感组CRP及GPⅡb／Ⅲa水平均升高（P〈0．05）。阿司匹林抵抗与性别、吸烟、糖尿病等因素无关。结论利用血栓弹力图检测老年冠心病患者阿司匹林抵抗的发牛率．其伴有较高CRP及GPⅡb／Ⅲa水平。

Related factors investigation of aspirin resistance in elder patients with coronary heart disease by thrombelastog- raphy

Abstract：Objective To observe the incidence of aspirin resistance in the elder patients with coronary heart disease by thrombelastography and to investigate the factors leading to aspirin resistance. Methods We studied two hundred and forty-five elder patients with coronary heart disease between January 2012 and June 2012 who received aspirin greater than lOOmg per day randomly for over 30 days. Aspirin resistance was analyzed by thrombelastography. Platelet activation inde- xes CD62p, CD63 and GP Ⅱb/Ⅲ a were detected by flow cytometry （ FCM ）. Biochemical, homocysteine and CRP were measured at the same time. Results Compared with the AS group, C-reactive protein and GPⅡb/Ⅲ a were increased sta- tistically in the elder patients with CAD of the AR group. In addition, aspirin resistance was not correlated with sexual dis- tinction,smoking history and diabetes. Conclusion Thrombelastography can be used to measure the incidence of aspirin resistance. The patients with high CRP and GP Ⅱb/Ⅲa levels are more predisposed to aspirin resistance.