Hp感染与口周皮炎的相关性分析及抗Hp三联疗法疗效分析

目的探讨幽门螺杆菌（Hp）感染与口周皮炎的关系，以及抗Hp三联疗法治疗Hp阳性的VI周皮炎的临床疗效。方法选取VI周皮炎患者196例、健康志愿者30例，均行14C一尿素呼气试验进行Hp检测，比较2组的Hp阳性率。再将Hp阳性的121周皮炎患者随机分为观察组和对照组，对照组仅使用5％硫磺霜适量涂患处，3次／d；观察组在对照组的基础上，再予以抗Hp三联治疗，2组均连续治疗2周。比较观察组和对照组治疗前后的皮损症状评分、临床疗效、不良反应、Hp清除率和口周皮炎复发率。结果口周皮炎患者Hp阳性率为85．7％，健康志愿者Hp阳性率为13．3％，2组Hp阳性率比较，差异具有统计性意义（x2=9．87，P〈0．01）。观察组与对照组治疗后，皮损症状评分均显著降低（t=8．70，5．67，P〈0．01），且观察组评分低于对照组（t：4．11，P〈0．05）。观察组与对照组治疗总有效率分别为90．5％和64．3％，差异具有统计学意义（x2=4．81，P〈0．05）；Hp清除率分别为90．5％、8．3％（x。=8．68，P〈0．01），口周皮炎复发率分别为3．6％、19．0％（x。=6．73，P〈0．叭）。治疗过程中，均未见明显的不良反应。结论口周皮炎患者Hp检出率较高，抗Hp三联疗法有效地缓解了口周皮炎的皮损症状，清除了Hp感染，降低了口周皮炎的近期复发率，且具有较高的安全性，对口周皮炎的临床治疗具有一定的借鉴和指导意义。

Correlation between helicobacter pylori infection and perioral dermatitis and effect of anti-hp triple therapy

Objective To explore the relationship between Helicobacter pylori（Hp） infection and perioral dermatitis, and the clinical effect of anti-Hp＇ s triple therapy in treatment of Hp related perioral dermatitis. Methods A total of 196 pa- tients with perioral dermatitis and 30 healthy volunteers were recruited, andl4C- urea breath test were performed to deter- mine Hp positive rate. Then the patients with positive Hp were randomly divided into observation group and control group. The patients in the control group received the coating of 5% sulfur cream on wounded area, and patients in the observation group received additional anti-Hp＇ s triple therapy, the courses in both groups were 2 weeks. Skin lesions score before and after treatment, clinical efficacy, adverse reactions, Hp removal rate and recurrence rate of perioral dermatitis were com- pared between the two groups. Results Hp positive rate in perioral dermatitis patients was 85.7% , and in healthy volun- teers was 13.3%, there was statistical difference （X2 = 9.87,P 〈 0.01 ）. After the treatment, skin lesions score in the ob- servation group and control group were both reduced （ t = 8.70,5.67, P 〈 0.01 ）, and the score in the observation group was lower than that of the control group （ t = 4. 11, P 〈 0.05 ）. Total effective rate in the observation group and control group were 90.5 % and 64.3 % , respectively （ 2 = 4.81,P 〈 0.05 ） , Hp removal rate was 90.5% and 8.3 % （ X2 = 8.68, P 〈0.01 ） ,and perioral dermatitis recurrence rates were 3.6% and 19% （ X2 = 6.73 ,P 〈 0.01 ）. In the course of treat- ment, there was no obvious adverse reaction. Conclusion Patients with perioral dermatitis have a high positive rate of Hp, and anti-Hp＇ s triple therapy, with a high security, can effectively relieve the skin lesions of perioral dermatitis, remove Hp, and reduce the recurrence rate of perioral dermatitis. It has certain reference and guide to the clinical treatment of perioral dermatitis.