影响红细胞输注效果的多因素 Logistic 回归分析

目的探讨影响红细胞输注效果的相关临床因素。方法回顾性分析浙江丽水地区2008年1月—2010年6月行红细胞输注的患者892例，共输注红细胞1132例次。其中输注有效962例次，无效170例次。采用二元条件Lotistic回归分析可能影响红细胞输注效果的因素。结果单因素分析显示输血史（x2=81．49，P=0．00）、感染（X2=33．32，P=0．00）、肝脾肿大（x2=4．81，P=0．03）和恶性肿瘤（x2=105．7，P=0．00）与红细胞输注效果有关；二元条件Logistic回归分析显示输血史（OR=2．41，P=0．001）和恶性肿瘤（OR=2．86，P=0．00）是影响红细胞输注效果的独立因素。结论有输血史的恶性肿瘤患者发生无效红细胞输注的风险相对较高。

A logistic regression analysis of related factors for red blood cell transfusion

Objective To evaluate the clinical factors associated with red blood cell transfusion effectiveness. Methods 446 patients （566 transfusions） received red blood cell transfusion from Jan 2008 to Jun 2010 were analyzed retrospectively. 807 and 85 patients were in the effective transfusion and ineffective transfusion group respectively. The potential factors associated with red blood cell transfusion effectiveness were evaluated by the method of Logistic regression. Results The single factor analysis showed that blood transfusion history（ X2 = 81.49 ,P = 0.00 ） , the infection（ X2 = 33.32 ,P = 0.00 ）, the splenohepatomegalia （ X2 = 4.81, P = 0.03 ）, and the malignant disease （ X2 = 105.7, P = 0.00） were associated with the effectiveness of red blood cell transfusion. Binary conditional logistic regression analysis showed that the blood transfusion history （ OR = 2.41, P = 0. 001 ） and the malignant disease （ OR = 2.86, P = 0. 00 ） were independent factors for effectiveness of red blood cell transfusion. Conclusion The patients with blood transfusion history and malignant disease were at the high risk for ineffectiveness of red cell blood transfusion.