隐性梅毒患者外周血T淋巴细胞亚群对驱梅治疗疗效的影响

目的　观察隐性梅毒患者外周血T淋巴细胞亚群对苄星青霉素G驱梅疗效的影响。方法　应用流式细胞仪(FCM)检测12例正常人(A组)及12例二期梅毒(B组)、12例早期隐性梅毒(C组)及12例晚期隐性梅毒(D组)治疗前外周血T细胞亚群。结果　四组之间CD3+差异无显著性(P均>0. 05),而CD4+,CD8+,CD4+ /CD8+差异有显著性(P均<0. 05); 隐性梅毒患者经苄星青霉素G驱梅治疗并随访6个月, 有效者治疗前CD4+,CD4+ /CD8+明显高于无效者(P均<0. 05)。结论　隐性梅毒患者的细胞免疫功能低下;外周血T细胞亚群对苄星青霉素G驱梅效果可能有重要影响,并对预测苄星青霉素G治疗隐性梅毒效果有重要意义。

Effect of T Lymphocyte Subset on the Efficacy of Benzathine Penicillin G in Patients with Latent Syphilis

Objective To observe the effect of T lymphocyte subset in patients with latent syphilis(LS)on the efficacy of Benzathine penicillin G. Methods T lymphocyte subset was assessed with flow cytometry (FCM). Results Among the four groups, the numbers of the CD3 + T cells show no difference ( P >0.05), but the numbers of the CD4 +,CD8 + T cells and the ratio of CD4 +/CD8 + had significant difference ( P <0.05); After six months of Benzathine penicillin G treatment, it was found that effective patients whose numbers of CD4 + and the ratio of CD4 +/CD8 + were significantly higher before treatment than that of non effective cases( P <0.05).Conclusion Cellular immunity in patients with LS is more suppressive, and T lymphocyte subset could effect and evaluate the efficacy of Benzathine penicillin G for LS.