放置VCu200宫内节育器后五年内的铜离子释放规律

本文研究了放置含铜V 型宫内节育器(VCu200 IUD)后五年内的宫颈粘液含铜量,从而了解VCu200 IUD 的使用年限。随机选择带VCu200 IUD 者1、3、6、12个月各30例;24、36、48、60个月各20例。同时随机选择带不锈钢IUD 者10例,并选16例不带器妇女作正常位对照。于月经第20～23天用玻璃吸管吸取宫颈粘液0.2～0.4克,用无火焰原子吸收分光光度计测铜离子浓度。结果带VCu200 IUD 者各期平均宫颈粘液的含铜量为2.61、1.98、1.96、1.82、1.22、1.20、1.15、0.98微克/每克粘液湿重,与正常未带器者及带不锈钢器者各期的含铜量均有显著差异(p<0.05),释放量虽随时间延长而逐渐减少(y=-0.2764x+2.2340),至第五年与未带器者相比,仍有显著差异(p<0.05),提示VCu200 IUD 使用五年仍有生物活性。

RELEASE OF COPPER IONS AFTER INSERTION OF VCu200 IUDs

In order to understand the life span of VCu200 IUDs in situ, the copper-ion concentrations in the cervical mucus were assayed after insertion of VCu200 IUDs for 5 years. Copper-ion concentrations were measured at random in 30 cases each of 1, 3, 6, and 12 monthth VCu 200 IUD users and 20 cases each of 24, 36, 48, and 60 month users. At the same time, 10 cases of the inserted-ring users were similarly studied for comparison. In addition, to obtain the normal copper-ion concentrations in the cervical mucus during the proliferative phase (8th-9th day), mid-period phase (10th-14th day) and the secretory phase (20th-23rd day) of a norma cycle, 16 cases of nonusers were selected as control. The measurements were assayed by a non-flame atomic absorption spectrophotometer. Samples of 0.2-0.4 gms of cervical mucus were collected in a glass tube from the IUD users on the 20th-23rd day of the menstrual period. There is a significant difference between VCu200 IUD users and nonusers (p 0.01) and ring users (p 0.01). The copper-ions released in VCu200 IUD users in different months were 2.61, 1.98, 1.96, 1.82, 1.22, 1.20, 1.15, 0.98 ug/g. w. w., respectively. The equation for regression line is y = -0.2764x+2.2340, which shows that the amount released decreased wtih increased time interval. However, the released amount of copper-ions at the end of 60 months was still higher in the users than in the nonusers (p 0.05). These results indicate that VCu200 IUDs can be left in situ at least 5 years without decreasing its biological activity in contraception.