细胞自噬与肿瘤发生

细胞自噬(autophagy)是广泛存在于真核细胞中的生命现象,是机体一种重要的防御和保护机制。细胞可以通过自噬和溶酶体,消除、降解、消化受损、变性、衰老和失去功能的细胞、细胞器、变性蛋白质与核酸等生物大分子,为细胞的重建、再生和修复提供必须原料,实现细胞的再循环和再利用。自噬异常与肿瘤的发生、发展密切相关,涉及影响肿瘤进程的多个层面,包括肿瘤基因、细胞周期、血管生成及溶酶体变化等。因此,通过对自噬作用的研究,既进一步揭示肿瘤发生、发展的潜在机制,也可能为肿瘤的预防和治疗提供新的思路。

Autophagy and Cancer Treatment

Autophagy is widely exist in eukaryotic cells,the phenomenon of life,is an important body defense and protection mechanisms.Cells can through the autophagy and the lysosome,eliminate,degradation,digestivedamage,degeneration,aging and lose function of cells,organelles,denatured protein and nucleic acid and biological macromolecules,for the reconstruction of the cells,regeneration and repair provide the necessary raw materials,achieve cell recycling and reuse.Autophagy abnormalities and tumors development is closely related to the tumor process involving multiple levels of influence,including oncogenes,cell cycle,angiogenesis and lysosome changes,etc.Therefore,through the study of effects of autophagy,not only to further reveals tumor occurrence and development of potential mechanism,but also may provide cancer prevention and treatment of new ideas.